| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Riebel, Lisa-Marie Brunner, Caroline Nothdurfter, Simon Wein, Jens Schwarzbach, Philippe Liere, Michael Schumacher, Rainer Rupprech. Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression. European archives of psychiatry and clinical neuroscience. 2024-07-08. PMID:38976049. |
recently, the gamma-aminobutyric acid (gaba) system has come into focus for the treatment of anxiety, postpartum depression, and major depressive disorder. |
2024-07-08 |
2024-07-11 |
Not clear |
| Hitoshi Osaka, Tetsufumi Kanazaw. Emerging trends in antipsychotic and antidepressant drug development: Targeting nonmonoamine receptors and innovative mechanisms. PCN reports : psychiatry and clinical neurosciences. vol 2. issue 4. 2024-06-13. PMID:38868733. |
another notable candidate is zuranolone, operating as a gaba a receptor-positive allosteric modulator, showcasing efficacy in treating major depressive disorder (mdd) and postpartum depression. |
2024-06-13 |
2024-06-15 |
Not clear |
| Maria Ironside, Jessica M Duda, Amelia D Moser, Laura M Holsen, Chun S Zuo, Fei Du, Sarah Perlo, Christine E Richards, Xi Chen, Lisa D Nickerson, Kaylee E Null, Shiba M Esfand, Madeline M Alexander, David J Crowley, Meghan Lauze, Madhusmita Misra, Jill M Goldstein, Diego A Pizzagall. Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects. The American journal of psychiatry. 2024-04-30. PMID:38685857. |
the authors sought to address a critical gap in knowledge, namely, how stress circuitry is functionally affected by glucocorticoids and gaba in current or remitted major depressive disorder (mdd). |
2024-04-30 |
2024-05-03 |
Not clear |
| Dina N Ali, Hossam M Ali, Matthew R Lopez, Shinwoo Kang, Doo-Sup Cho. Astrocytic GABAergic Regulation in Alcohol Use and Major Depressive Disorders. Cells. vol 13. issue 4. 2024-02-23. PMID:38391931. |
accumulating evidence demonstrates that astrocytic gaba dysregulation is implicated in psychiatric disorders, including alcohol use disorder (aud) and major depressive disorder (mdd), the most prevalent co-occurring psychiatric disorders. |
2024-02-23 |
2024-02-25 |
Not clear |
| Timur Liwinski, Undine E Lang, Annette B Brühl, Else Schneide. Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders through the Gut-Brain Axis. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137351. |
exploring the therapeutic potential of gamma-aminobutyric acid in stress and depressive disorders through the gut-brain axis. |
2023-12-23 |
2023-12-25 |
Not clear |
| Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Jean-Michel Le Melled. Decreased GABA+ ratios referenced to creatine and phosphocreatine in the left dorsolateral prefrontal cortex of females of reproductive age with major depression. Journal of psychiatry & neuroscience : JPN. vol 48. issue 4. 2023-08-22. PMID:37607825. |
it has been suggested that the dorsolateral prefrontal cortex (dlpfc), especially the left dlpfc, has an important role in the pathophysiology and the treatment of major depressive disorder (mdd); furthermore, the contributory and antidepressant role of γ-aminobutyric acid (gaba) is increasingly recognized. |
2023-08-22 |
2023-09-07 |
Not clear |
| Yu-Ting Hu, Zhong-Lin Tan, Dusan Hirjak, Georg Northof. Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations. Molecular psychiatry. 2023-07-26. PMID:37495889. |
the excitation-inhibition (e/i) imbalance is an important molecular pathological feature of major depressive disorder (mdd) as altered gaba and glutamate levels have been found in multiple brain regions in patients. |
2023-07-26 |
2023-08-14 |
human |
| T V Davydova, T I Nevidimova, L A Vetrile, I A Zakharova, D N Savochkina, S A Galkin, N A Bokha. Correlation of Antibodies to Neurotransmitters in the Sera of Women with Alcohol Dependence and Depressive Disorders. Bulletin of experimental biology and medicine. vol 171. issue 6. 2021-11-02. PMID:34705169. |
comparative analysis of blood sera from women with alcohol dependence and depressive disorders or from conditionally healthy women revealed reduced level of antibodies to dopamine, norepinephrine, serotonin, glutamate, and gaba in blood serum in women with dysthymic disorder and a depressive episode and their increased content in women with alcohol dependence in combination with depressive disorders. |
2021-11-02 |
2023-08-13 |
Not clear |
| Kate E M Godfrey, Suresh D Muthukumaraswamy, Cathy M Stinear, Nicholas Hoe. Effect of rTMS on GABA and glutamate levels in treatment-resistant depression: An MR spectroscopy study. Psychiatry research. Neuroimaging. vol 317. 2021-10-25. PMID:34479176. |
alterations in levels of neurotransmitters γ-aminobutyric acid (gaba) and glutamate may underlie the mechanism by which repetitive transcranial magnetic stimulation (rtms) has efficacy as a treatment for major depressive disorder (mdd). |
2021-10-25 |
2023-08-13 |
Not clear |
| Joshua T Kantrowitz, Zhengchao Dong, Matthew S Milak, Rain Rashid, Lawrence S Kegeles, Daniel C Javitt, Jeffrey A Lieberman, J John Man. Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34354048. |
ventromedial prefrontal cortex/anterior cingulate cortex glx, glutamate, and gaba levels in medication-free major depressive disorder. |
2021-10-11 |
2023-08-13 |
Not clear |
| Joshua T Kantrowitz, Zhengchao Dong, Matthew S Milak, Rain Rashid, Lawrence S Kegeles, Daniel C Javitt, Jeffrey A Lieberman, J John Man. Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34354048. |
glutamate (glu) and gamma-aminobutyric acid (gaba) are implicated in the pathophysiology of major depressive disorder (mdd). |
2021-10-11 |
2023-08-13 |
Not clear |
| Rajib Hossain, Khattab Al-Khafaji, Rasel Ahmed Khan, Chandan Sarkar, Md Shahazul Islam, Dipta Dey, Divya Jain, Farhana Faria, Rukaya Akbor, Olubunmi Atolani, Sónia M R Oliveira, Abolghasem Siyadatpanah, Maria de Lourdes Pereira, Muhammad Torequl Isla. Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABA Pharmaceuticals (Basel, Switzerland). vol 14. issue 8. 2021-08-31. PMID:34451819. |
quercetin and/or ascorbic acid modulatory effect on phenobarbital-induced sleeping mice possibly through gaba depressive disorder is a recurrent illness that affects large numbers of the general population worldwide. |
2021-08-31 |
2023-08-13 |
mouse |
| Ji-Hong Liu, Ze-Lin Li, Yi-Si Liu, Huai-De Chu, Neng-Yuan Hu, Ding-Yu Wu, Lang Huang, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Ga. Astrocytic GABA Neuroscience bulletin. vol 36. issue 7. 2021-07-19. PMID:32166647. |
astrocytic gaba major depressive disorder (mdd) is a common mood disorder that affects almost 20% of the global population. |
2021-07-19 |
2023-08-13 |
Not clear |
| Vuong Truong, Paul Z Cheng, Hsin-Chien Lee, Timothy J Lane, Tzu-Yu Hsu, Niall W Dunca. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis. Psychiatry research. Neuroimaging. vol 308. 2021-05-20. PMID:33385764. |
occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: an mrs study and meta-analysis. |
2021-05-20 |
2023-08-13 |
Not clear |
| Vuong Truong, Paul Z Cheng, Hsin-Chien Lee, Timothy J Lane, Tzu-Yu Hsu, Niall W Dunca. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis. Psychiatry research. Neuroimaging. vol 308. 2021-05-20. PMID:33385764. |
the neurotransmitters gaba and glutamate have been suggested to play a role in major depressive disorder (mdd) through an imbalance between cortical inhibition and excitation. |
2021-05-20 |
2023-08-13 |
Not clear |
| Ajay Sarawagi, Narayan Datt Soni, Anant Bahadur Pate. Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder. Frontiers in psychiatry. vol 12. 2021-05-16. PMID:33986699. |
glutamate and gaba homeostasis and neurometabolism in major depressive disorder. |
2021-05-16 |
2023-08-13 |
Not clear |
| Xue Mei Song, Xi-Wen Hu, Zhe Li, Yuan Gao, Xuan Ju, Dong-Yu Liu, Qian-Nan Wang, Chuang Xue, Yong-Chun Cai, Ruiliang Bai, Zhong-Lin Tan, Georg Northof. Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder. Molecular psychiatry. 2021-04-17. PMID:33863994. |
reduction of higher-order occipital gaba and impaired visual perception in acute major depressive disorder. |
2021-04-17 |
2023-08-13 |
human |
| Kathleen L Benson, Ryan Bottary, Laura Schoerning, Lee Baer, Atilla Gonenc, J Eric Jensen, John W Winkelma. Journal of affective disorders. vol 274. 2021-02-15. PMID:32663996. |
both major depressive disorder (mdd) and primary insomnia (pi) have been linked to deficiencies in cortical γ-aminobutyric acid (gaba) and glutamate (glu) thus suggesting a shared neurobiological link between these two conditions. |
2021-02-15 |
2023-08-13 |
Not clear |
| Mitra Heshmati, Daniel J Christoffel, Katherine LeClair, Flurin Cathomas, Sam A Golden, Hossein Aleyasin, Gustavo Turecki, Allyson K Friedman, Ming-Hu Han, Caroline Menard, Scott J Russ. Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 32. 2021-01-04. PMID:32561672. |
here we extend this observation by examining the role of two other inhibitory synapse constituents, vesicular gaba transporter (vgat) and gephyrin, in the nac of male mice that underwent chronic social defeat stress (csds) and in patients with major depressive disorder (mdd). |
2021-01-04 |
2023-08-13 |
mouse |
| J W Liao, S S Wang, H H Yang, P Ma, C R Li, J Y Pa. [Comparative analysis of serum glutamate and gamma-aminobutyric acid levels in patients with bipolar depressive disorder and major depression disorder]. Zhonghua yi xue za zhi. vol 100. issue 23. 2020-08-10. PMID:32536126. |
[comparative analysis of serum glutamate and gamma-aminobutyric acid levels in patients with bipolar depressive disorder and major depression disorder]. |
2020-08-10 |
2023-08-13 |
Not clear |