| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed Salih, Reem Mohamed Osman, Wala Alim, Leena Khalid, Wafa Sosal, Danya Ibrahim, Yassir Mahgou. Agitated Depression Associated With Flurazepam Discontinuation. Case reports in psychiatry. vol 2024. 2024-09-30. PMID:39345783. |
this case provides insight into this unique variant of depression and the role of gaba agonists in its pathology and management. |
2024-09-30 |
2024-10-02 |
Not clear |
| Xenia Gonda, Frank I Tarazi, Peter Dom. The emergence of antidepressant drugs targeting GABA Biochemical pharmacology. 2024-08-15. PMID:39147329. |
the emergence of antidepressant drugs targeting gaba depression is among the most common psychiatric illnesses, which imposes a major socioeconomic burden on patients, caregivers, and the public health system. |
2024-08-15 |
2024-08-18 |
Not clear |
| Mehmet Arif Icer, Buse Sarikaya, Emine Kocyigit, Büşra Atabilen, Menşure Nur Çelik, Raffaele Capasso, Duygu Ağagündüz, Ferenc Budá. Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects. Foods (Basel, Switzerland). vol 13. issue 15. 2024-08-10. PMID:39123629. |
in addition to the possible positive effects of gaba, called a postbiotic, on neuroprotection, improving sleep quality, alleviating depression and relieving pain, the various health benefits of gaba-enriched foods such as antidiabetic, antihypertension, and anti-inflammatory effects are also being investigated. |
2024-08-10 |
2024-08-13 |
human |
| Eugenia D Namiot, Diana Smirnovová, Aleksandr V Sokolov, Vladimir N Chubarev, Vadim V Tarasov, Helgi B Schiöt. Depression clinical trials worldwide: a systematic analysis of the ICTRP and comparison with ClinicalTrials.gov. Translational psychiatry. vol 14. issue 1. 2024-07-31. PMID:39085220. |
this analysis addresses 40 approved drugs for depression treatment including new drug classes like gaba modulators and nmda antagonists that are offering new prospects for treating mdd, including drug-resistant depression and postpartum depression subtypes. |
2024-07-31 |
2024-08-03 |
Not clear |
| Madiha Rasheed, Adnan Tahir, Mohamed Maazouzi, Han Wang, Yumeng Li, Zixuan Chen, Yulin Den. Interplay of miRNAs and molecular pathways in spaceflight-induced depression: Insights from a rat model using simulated complex space environment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-22. PMID:39037540. |
among the degs identified, the in silico analysis highlighted their involvement in crucial pathways such as glutamatergic signaling, gaba synaptic pathway, and calcium signaling, implicating their role in spaceflight-induced depression. |
2024-07-22 |
2024-07-24 |
rat |
| Xinzi Liu, Yuxin Li, Yixiang Mo, Baoling Chen, Xusheng Hou, Jianbin Zhu, Yongzhou Xu, Jingyue Xue, Haitao Wen, Xianlong Wang, Zhibo We. GABAergic imbalance in Parkinson's disease-related depression determined with MEGA-PRESS. NeuroImage. Clinical. vol 43. 2024-07-20. PMID:39032208. |
therefore, this study aimed to explore the changes in γ-aminobutyric acid (gaba) and glutamate plus glutamine (glx) levels in patients with pd with or without depression determined using mescher-garwood point resolved spectroscopy (mega-press). |
2024-07-20 |
2024-07-24 |
Not clear |
| Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Keiko Takasu, Koichi Ogaw. Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cortex. Frontiers in cellular neuroscience. vol 18. 2024-06-20. PMID:38899227. |
one hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ-aminobutyric acid-gated chloride channel (gaba |
2024-06-20 |
2024-06-22 |
Not clear |
| Hitoshi Osaka, Tetsufumi Kanazaw. Emerging trends in antipsychotic and antidepressant drug development: Targeting nonmonoamine receptors and innovative mechanisms. PCN reports : psychiatry and clinical neurosciences. vol 2. issue 4. 2024-06-13. PMID:38868733. |
another notable candidate is zuranolone, operating as a gaba a receptor-positive allosteric modulator, showcasing efficacy in treating major depressive disorder (mdd) and postpartum depression. |
2024-06-13 |
2024-06-15 |
Not clear |
| Maria Katharina Grötsch, Ulrike Ehler. Allopregnanolone in the peripartum: Correlates, concentrations, and challenges - A systematic review. Psychoneuroendocrinology. vol 166. 2024-05-17. PMID:38759520. |
as a positive allosteric modulator of gamma-aminobutyric acid (gaba) receptors, allo seems to have antidepressant and anxiolytic effects, and was therefore approved as a specific medication for the treatment of postpartum depression in 2019. |
2024-05-17 |
2024-05-27 |
Not clear |
| Shashi B Singh, Atit Tiwari, Maanya R Katta, Riju Kafle, Cyrus Ayubcha, Krishna H Patel, Yash Bhattarai, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revhei. The utility of PET imaging in depression. Frontiers in psychiatry. vol 15. 2024-05-08. PMID:38711875. |
studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, gaba, and glutamate, which are linked to the pathophysiology of depression. |
2024-05-08 |
2024-05-27 |
Not clear |
| Scott J Mitchell, Grant D Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J Martin, Jerome D Swinny, Louise Kelly, John R Atack, Michael Paradowski, Jeremy J Lamber. Neurosteroid Modulation of Synaptic and Extrasynaptic GABA Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672476. |
neurosteroid modulation of synaptic and extrasynaptic gaba the recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid sage-217 (zuranolone) to treat postpartum depression (ppd) has encouraged further research to elucidate why these potent enhancers of gaba |
2024-04-27 |
2024-04-29 |
Not clear |
| A Kolobaric, C Andreescu, E Jašarević, C H Hong, H W Roh, J Y Cheong, Y K Kim, T S Shin, C S Kang, C O Kwon, S Y Yoon, S W Hong, H J Aizenstein, H T Karim, S J So. Gut microbiome predicts cognitive function and depressive symptoms in late life. Molecular psychiatry. 2024-04-25. PMID:38664490. |
poor current cognitive function associated with lower relative abundance of bifidobacterium, while greater gaba degradation associated with greater current depression severity. |
2024-04-25 |
2024-04-28 |
human |
| Alai Muheyati, Shanshan Jiang, Na Wang, Gang Yu, Ruibin S. Extrasynaptic GABA European journal of pharmacology. 2024-04-05. PMID:38580182. |
extrasynaptic gaba neuronal depression in the thalamus underlies anesthetic-induced loss of consciousness, while the precise sub-thalamus nuclei and molecular targets involved remain to be elucidated. |
2024-04-05 |
2024-04-10 |
Not clear |
| Jessica M Duda, Amelia D Moser, Maria Ironside, Kaylee E Null, Laura M Holsen, Chun S Zuo, Fei Du, Shiba M Esfand, Xi Chen, Sarah Perlo, Christine E Richards, Rachel Lobien, Madeline Alexander, Madhusmita Misra, Jill M Goldstein, Diego A Pizzagall. Effects of GABA, Sex, and Stress on Reward Learning in Current and Remitted Major Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2024-02-28. PMID:38417785. |
effects of gaba, sex, and stress on reward learning in current and remitted major depression. |
2024-02-28 |
2024-03-02 |
Not clear |
| Renu Sharma, Pranjal Bansal, Lokesh Saini, Nidhi Sharma, Richa Dhingr. Zuranolone, a neuroactive drug, used in the treatment of postpartum depression by modulation of GABA Pharmacology, biochemistry, and behavior. 2024-02-22. PMID:38387651. |
zuranolone, a neuroactive drug, used in the treatment of postpartum depression by modulation of gaba postpartum depression [ppd] is a prevalent and debilitating mood disorder that affects mothers in the weeks to months after childbirth. |
2024-02-22 |
2024-02-25 |
Not clear |
| Aparecida Patricia Guimarães, Helen Seidel, Larissa Vitalina de Medeiros Pires, Cristina Oliveira Trindade, Raianne Dos Santos Baleeiro, Perciliany Martins de Souza, Fernanda Guimarães Drummond E Silva, Daniel Barbosa Coelho, Lenice Kappes Becker, Emerson Cruz de Oliveir. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial. Journal of dietary supplements. 2024-02-07. PMID:38321713. |
gaba supplementation, increased heart-rate variability, emotional response, sleep efficiency and reduced depression in sedentary overweight women undergoing physical exercise: placebo-controlled, randomized clinical trial. |
2024-02-07 |
2024-02-09 |
human |
| Aparecida Patricia Guimarães, Helen Seidel, Larissa Vitalina de Medeiros Pires, Cristina Oliveira Trindade, Raianne Dos Santos Baleeiro, Perciliany Martins de Souza, Fernanda Guimarães Drummond E Silva, Daniel Barbosa Coelho, Lenice Kappes Becker, Emerson Cruz de Oliveir. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial. Journal of dietary supplements. 2024-02-07. PMID:38321713. |
gaba supplementation yielded ameliorations in depression scores as per the depression, anxiety, and stress scale (dass-21). |
2024-02-07 |
2024-02-09 |
human |
| Aparecida Patricia Guimarães, Helen Seidel, Larissa Vitalina de Medeiros Pires, Cristina Oliveira Trindade, Raianne Dos Santos Baleeiro, Perciliany Martins de Souza, Fernanda Guimarães Drummond E Silva, Daniel Barbosa Coelho, Lenice Kappes Becker, Emerson Cruz de Oliveir. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial. Journal of dietary supplements. 2024-02-07. PMID:38321713. |
gaba supplementation elicited noteworthy enhancements in heart rate variability, emotional response, depression mitigation, and sleep efficiency following a 90-day supplementation. |
2024-02-07 |
2024-02-09 |
human |
| Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Tami Shandro, Jean-Michel Le Melled. The impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression. Journal of affective disorders. 2024-01-20. PMID:38244791. |
the impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression. |
2024-01-20 |
2024-01-23 |
Not clear |
| Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Tami Shandro, Jean-Michel Le Melled. The impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression. Journal of affective disorders. 2024-01-20. PMID:38244791. |
the role played by medial prefrontal cortex (mpfc) glutamate (glu) and gamma-aminobutyric acid (gaba) in the pathophysiology and the treatment of major depression (md) is increasingly recognized. |
2024-01-20 |
2024-01-23 |
Not clear |