| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Milica Milicic, Balázs Gaszner, Gergely Berta, Erika Pintér, Viktória Kormo. The Lack of TRPA1 Ion Channel Does Not Affect the Chronic Stress-Induced Activation of the Locus Ceruleus. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339042. |
we investigated trpa1 knockout and wildtype mice using the cvms model of depression. |
2024-02-10 |
2024-02-12 |
mouse |
| Lingdi Nie, Liwen Jiang, John P Quinn, Blair D Grubb, Minyan Wan. TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization. International journal of molecular sciences. vol 22. issue 22. 2021-11-29. PMID:34830154. |
in this study, we explored the hypothesis that src family kinases (sfks) transmit trpa1 signaling in regulating cortical spreading depression (csd), calcitonin gene-related peptide (cgrp) release and neuroinflammation. |
2021-11-29 |
2023-08-13 |
mouse |
| Francesca Maestrelli, Elisa Landucci, Enrico De Luca, Giulia Nerli, Maria Camilla Bergonzi, Vieri Piazzini, Domenico E Pellegrini-Giampietro, Francesca Gullo, Andrea Becchetti, Francesco Tadini-Buoninsegni, Oscar Francesconi, Cristina Nativ. Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain. Pharmaceutics. vol 11. issue 12. 2020-09-28. PMID:31835593. |
trpa1 channels expressed in the central nervous system (cns) have a critical role in the modulation of cortical spreading depression (csd), which is a key pathophysiological basis of migraine pain. |
2020-09-28 |
2023-08-13 |
Not clear |
| Liwen Jiang, Dongqing Ma, Blair D Grubb, Minyan Wan. ROS/TRPA1/CGRP signaling mediates cortical spreading depression. The journal of headache and pain. vol 20. issue 1. 2019-04-24. PMID:30841847. |
this study aimed to understand their mechanisms in migraine by investigating the role of trpa1 in cortical spreading depression (csd) in vivo and exploring how reactive oxygen species (ros)/trpa1/cgrp interplay in regulating cortical susceptibility to csd. |
2019-04-24 |
2023-08-13 |
Not clear |
| Sayumi Kotani, Saki Irie, Masahiko Izumizaki, Hiroshi Onimar. Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations. Pflugers Archiv : European journal of physiology. vol 470. issue 2. 2019-01-23. PMID:28963585. |
the shortening of c4 inspiratory burst by eugenol was not reversed by capsazepine (trpv1 antagonist) or hc-030031 (trpa1 antagonist), whereas the depression was partially blocked by gaba |
2019-01-23 |
2023-08-13 |
rat |
| b' Juliana Cavalcante de Moura, Ma\\xc3\\xadra Macedo Noroes, Vanessa de Paula Soares Rachetti, Bruno Lob\\xc3\\xa3o Soares, Delia Preti, Romina Nassini, Serena Materazzi, Ilaria Maddalena Marone, Daiana Minocci, Pierangelo Geppetti, Elaine Cristina Gavioli, Eunice Andr\\xc3\\xa. The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice. British journal of pharmacology. vol 171. issue 18. 2015-05-26. PMID:24846744.' |
whereas the involvement of trpv1 in psychiatric disorders such as anxiety and depression has been reported, little is known regarding the role of trpa1 in these conditions. |
2015-05-26 |
2023-08-13 |
mouse |
| Bret F Bessac, Michael Sivula, Christian A von Hehn, Jasmine Escalera, Lauren Cohn, Sven-Eric Jord. TRPA1 is a major oxidant sensor in murine airway sensory neurons. The Journal of clinical investigation. vol 118. issue 5. 2008-07-01. PMID:18398506. |
in tests of respiratory function, trpa1(-/-) mice displayed profound deficiencies in hypochlorite- and hydrogen peroxide-induced respiratory depression as well as decreased oxidant-induced pain behavior. |
2008-07-01 |
2023-08-12 |
mouse |