| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Lou Zhang, Yan Sun, Zhang-Jie Wu, Ying Yin, Rui-Yi Liu, Ji-Chun Zhang, Zhang-Jin Zhang, Suk-Yu Yau, Hao-Xin Wu, Ti-Fei Yuan, Li Zhang, Miroslav Adzic, Gang Che. Hippocampal PACAP signaling activation triggers a rapid antidepressant response. Military Medical Research. vol 11. issue 1. 2024-07-24. PMID:39044298. |
implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (pacap) is investigated here to examine its role in mediating the rapid antidepressant response. |
2024-07-24 |
2024-07-26 |
Not clear |
| Ting-Bin Chen, Cheng-Chia Yang, I-Ju Tsai, Hao-Wen Yang, Yung-Chu Hsu, Ching-Mao Chang, Chun-Pai Yan. Neuroimmunological effects of omega-3 fatty acids on migraine: a review. Frontiers in neurology. vol 15. 2024-05-21. PMID:38770523. |
this interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (cgrp), pituitary adenylate cyclase activating polypeptide (pacap) and/or cortical spreading depression (csd) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (nlrp3) inflammasome formation, activated microglia, and reactive astrocytes. |
2024-05-21 |
2024-05-27 |
Not clear |
| Adrián Viudez-Martínez, Abraham B Torregrosa, Francisco Navarrete, María Salud García-Gutiérre. Understanding the Biological Relationship between Migraine and Depression. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397400. |
herein, this review explores this topic in further detail: firstly, by introducing the common epidemiological and risk factors for this comorbidity; secondly, by focusing on providing the cumulative evidence of common biological aspects, with a particular emphasis on the serotoninergic system, neuropeptides such as calcitonin-gene-related peptide (cgrp), pituitary adenylate cyclase-activating polypeptide (pacap), substance p, neuropeptide y and orexins, sexual hormones, and the immune system; lastly, by remarking on the future challenges required to elucidate the etiopathological mechanisms of migraine and depression and providing updated information regarding new key targets for the pharmacological treatment of these clinical entities. |
2024-02-24 |
2024-02-26 |
Not clear |
| Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszne. Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233039. |
epigenetic and neuronal activity markers suggest the recruitment of the prefrontal cortex and hippocampus in the three-hit model of depression in male pacap heterozygous mice. |
2022-10-14 |
2023-08-14 |
mouse |
| Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszne. Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy. Frontiers in endocrinology. vol 13. 2022-10-10. PMID:36213293. |
fluoxetine treatment supports predictive validity of the three hit model of depression in male pacap heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy. |
2022-10-10 |
2023-08-14 |
mouse |
| Daniel Pham, Beata Polgar, Tunde Toth, Adel Jungling, Norbert Kovacs, Istvan Balas, Endre Pal, Dora Szabo, Balazs Daniel Fulop, Dora Reglodi, Zalan Szanto, Robert Herczeg, Attila Gyenesei, Andrea Tama. Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson's disease focusing on correlations with motor symptoms. GeroScience. 2022-02-27. PMID:35220508. |
there were no significant correlations between pacap level with mds-updrs, type of pharmacological treatment, pdss-2 sleepiness, or depression (bdi) scales, but we found increased pacap level in patients with more severe sleepiness problems based on the ess scale. |
2022-02-27 |
2023-08-13 |
Not clear |
| Linyu Lu, Die Wu, Kai Wang, Juanjuan Tang, Gang Che. Beneficial Effects of Crocin against Depression via Pituitary Adenylate Cyclase-Activating Polypeptide. BioMed research international. vol 2020. 2021-04-16. PMID:32685478. |
recent studies have reported that the pituitary adenylate cyclase-activating polypeptide (pacap) signaling pathway is involved in the progression of depression. |
2021-04-16 |
2023-08-13 |
Not clear |
| József Farkas, László Á Kovács, László Gáspár, Anna Nafz, Tamás Gaszner, Balázs Ujvári, Viktória Kormos, Valér Csernus, Hitoshi Hashimoto, Dóra Reglődi, Balázs Gaszne. Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neuroscience. vol 354. 2018-03-15. PMID:28450265. |
urocortin1 neurons became over-active in cmvs-exposed pacap knock out (ko) mice with md180 history, suggesting the contribution of centrally projecting edinger-westphal nucleus to the reduced depression and anxiety level of stressed ko mice. |
2018-03-15 |
2023-08-13 |
mouse |
| József Farkas, László Á Kovács, László Gáspár, Anna Nafz, Tamás Gaszner, Balázs Ujvári, Viktória Kormos, Valér Csernus, Hitoshi Hashimoto, Dóra Reglődi, Balázs Gaszne. Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neuroscience. vol 354. 2018-03-15. PMID:28450265. |
construct and face validity of a new model for the three-hit theory of depression using pacap mutant mice on cd1 background. |
2018-03-15 |
2023-08-13 |
mouse |
| József Farkas, László Á Kovács, László Gáspár, Anna Nafz, Tamás Gaszner, Balázs Ujvári, Viktória Kormos, Valér Csernus, Hitoshi Hashimoto, Dóra Reglődi, Balázs Gaszne. Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neuroscience. vol 354. 2018-03-15. PMID:28450265. |
forced swim test indicated increased depression in cvms pacap heterozygous (hz) mice with md180 history, accompanied by elevated anxiety level in marble burying test. |
2018-03-15 |
2023-08-13 |
mouse |
| Viktória Kormos, László Gáspár, László Á Kovács, József Farkas, Tamás Gaszner, Valér Csernus, András Balogh, Hitoshi Hashimoto, Dóra Reglődi, Zsuzsanna Helyes, Balázs Gaszne. Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers. Neuroscience. vol 330. 2017-07-11. PMID:27282087. |
we conclude that pacap deficiency affects neuronal reactivity in a brain area-specific manner in stress centers, as well as in ovbst-crf, cpew-ucn1 and 5ht-dr neurons leading to reduced cvms response and altered depression level. |
2017-07-11 |
2023-08-13 |
mouse |
| Masaya Tohyama, Shingo Miyata, Tsuyoshi Hattori, Shoko Shimizu, Shinsuke Matsuzak. Molecular basis of major psychiatric diseases such as schizophrenia and depression. Anatomical science international. vol 90. issue 3. 2016-09-12. PMID:25595671. |
recently several potential susceptibility genes for major psychiatric disorders (schizophrenia and major depression) such as disrupted-in-schizophrenia 1(disc1), dysbindin and pituitary adenylate cyclase-activating polypeptide (pacap) have been reported. |
2016-09-12 |
2023-08-13 |
Not clear |
| Tomris Mustaf. Pituitary adenylate cyclase-activating polypeptide (PACAP): a master regulator in central and peripheral stress responses. Advances in pharmacology (San Diego, Calif.). vol 68. 2014-05-29. PMID:24054157. |
pacap receptor antagonists could have therapeutic relevance in preventing hyperactivity of the hpa axis and offering protection against chronic stress-associated anxiety and depression. |
2014-05-29 |
2023-08-12 |
Not clear |
| Albert Pinhasov, Elimelech Nesher, Moshe Gross, Gadi Turgeman, Anatoly Kreinin, Gal Yadi. The role of the PACAP signaling system in depression. Current pharmaceutical design. vol 17. issue 10. 2011-09-12. PMID:21524254. |
the role of the pacap signaling system in depression. |
2011-09-12 |
2023-08-12 |
Not clear |
| H Mulder, R Uddman, K Moller, Y Z Zhang, E Ekblad, J Alumets, F Sundle. Pituitary adenylate cyclase activating polypeptide expression in sensory neurons. Neuroscience. vol 63. issue 1. 1995-04-25. PMID:7898655. |
therefore, the recently described effects of pacap--cutaneous vasodilation, potentiation of oedema formation and depression of nociceptive spinal reflexes--may be physiological and related to neurogenic inflammation and modulation of pain transmission. |
1995-04-25 |
2023-08-12 |
rat |