| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E V Ponomareva, L V Androsova, S A Krinsky, S I Gavrilov. [Efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with Mild Cognitive Impairment: a three-year prospective comparative study]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 124. issue 4. Vyp. 2. 2024-05-02. PMID:38696157. |
to study the efficacy and safety of the use of annual course therapy of choline alfoscerate (ca) as a drug potentially capable of slowing or preventing the transition of amnesic type mild cognitive impairment (amci) into clinically pronounced dementia in a three-year open comparative study, as well as to explore the possibility of predicting the preventive effect of such therapy based on a number of clinical and biological parameters. |
2024-05-02 |
2024-05-04 |
Not clear |
| E V Ponomareva, L V Androsova, S A Krinsky, S I Gavrilov. [Efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with Mild Cognitive Impairment: a three-year prospective comparative study]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 124. issue 4. Vyp. 2. 2024-05-02. PMID:38696157. |
[efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with mild cognitive impairment: a three-year prospective comparative study]. |
2024-05-02 |
2024-05-04 |
Not clear |
| Thomas A Bellio, Jessenia Y Laguna-Torres, Mary S Campion, Jay Chou, Sheila Yee, Jan K Blusztajn, Tiffany J Mellot. Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in AppNL-G-F Alzheimer's disease model mice. PloS one. vol 19. issue 2. 2024-02-06. PMID:38315685. |
together, these results demonstrate that perinatal choline supplementation is capable of preventing cognitive deficits and dampening amyloidosis in appnl-g-f mice and suggest that ensuring adequate choline consumption during early life may be a valuable method to prevent or reduce ad dementia and neuropathology. |
2024-02-06 |
2024-02-09 |
mouse |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin Fa Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. The American journal of clinical nutrition. vol 116. issue 5. 2023-05-19. PMID:37208066. |
the positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or alzheimer's disease (ad) in humans is unclear. |
2023-05-19 |
2023-08-14 |
human |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin Fa Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. The American journal of clinical nutrition. vol 116. issue 5. 2023-05-19. PMID:37208066. |
is dietary choline intake related to dementia and alzheimer's disease risks? |
2023-05-19 |
2023-08-14 |
human |
| Getu Gamo Sagaro, Enea Traini, Francesco Ament. Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683513. |
choline alphoscerate (alpha glyceryl phosphorylcholine, α-gpc) is a choline-containing phospholipid used as a medicine or nutraceutical to improve cognitive function impairment occurring in neurological conditions including adult-onset dementia disorders. |
2023-01-23 |
2023-08-14 |
Not clear |
| Paul L Wood, Randall L Woltje. Serine ether glycerophospholipids: Decrements in the frontal cortex associated with mild cognitive impairment and Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-08-25. PMID:36004004. |
the roles of these lipids in the processes involved in the development of dementia are not understood but choline and ethanolamine vinyl-ether gpl (i.e., plasmalogens) are decreased in the brains of subjects with dementia. |
2022-08-25 |
2023-08-14 |
human |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin F A Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risk: results from the Framingham Heart Study. The American journal of clinical nutrition. 2022-08-02. PMID:35918258. |
the positive association of choline for cognition has been reported in both animal and human studies, yet the association of choline with the risk of incident dementia or alzheimer's disease (ad) in humans is unclear. |
2022-08-02 |
2023-08-14 |
human |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin F A Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risk: results from the Framingham Heart Study. The American journal of clinical nutrition. 2022-08-02. PMID:35918258. |
is dietary choline intake related to dementia and alzheimer's disease risk: results from the framingham heart study. |
2022-08-02 |
2023-08-14 |
human |
| Ana María López-Sobaler, Ana M Lorenzo Mora, M ª Dolores Salas González, África Peral Suárez, Aránzazu Aparicio, Rosa M ª Orteg. [Importance of choline in cognitive function]. Nutricion hospitalaria. vol 37. issue Spec No2. 2021-10-18. PMID:32993309. |
in adults and the elderly, choline intake has been associated with better performance in some cognitive functions and a lower incidence of dementia. |
2021-10-18 |
2023-08-13 |
Not clear |
| Hira Rafi, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, Muhammad Farha. Comparative Effectiveness of Agmatine and Choline Treatment in Rats with Cognitive Impairment Induced by AlCl Current clinical pharmacology. vol 15. issue 3. 2021-09-15. PMID:31622210. |
dietary intake of choline showed correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias. |
2021-09-15 |
2023-08-13 |
human |
| Barry S Baumel, P Murali Doraiswamy, Marwan Sabbagh, Richard Wurtma. Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review. Neurology and therapy. vol 10. issue 1. 2021-06-04. PMID:33368017. |
a multinutrient enriched with uridine, choline, and dha developed to support brain function has been evaluated in randomized controlled trials covering a spectrum of dementia from mci to moderate ad. |
2021-06-04 |
2023-08-13 |
human |
| Audun Skjaerseth Hildre, Stein-Erik Hafstad Solvang, Dag Aarsland, Øivind Midtun, Adrian McCann, Arne Olav Ervik, Ottar Nygård, Per Magne Ueland, Jan Erik Nordrehaug, Lasse Melvaer Gii. Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia. Brain research. vol 1726. 2021-03-29. PMID:31654640. |
components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia. |
2021-03-29 |
2023-08-13 |
Not clear |
| Maija P T Ylilauri, Sari Voutilainen, Eija Lönnroos, Heli E K Virtanen, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtane. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition. vol 110. issue 6. 2020-04-02. PMID:31360988. |
associations of dietary choline intake with risk of incident dementia and with cognitive performance: the kuopio ischaemic heart disease risk factor study. |
2020-04-02 |
2023-08-13 |
Not clear |
| Song Hee Lee, Bo Young Choi, Jin Hee Kim, A Ra Kho, Min Sohn, Hong Ki Song, Hui Chul Choi, Sang Won Su. Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain research. vol 1654. issue Pt A. 2017-05-24. PMID:27765578. |
choline alfoscerate (α-gpc) is a common choline compound and acetylcholine precursor in the brain, which has been shown to be effective in the treatment of alzheimer's disease and dementia. |
2017-05-24 |
2023-08-13 |
rat |
| Ryouta Maeba, Megumi Nishimukai, Shin-ichi Sakasegawa, Daisuke Sugimori, Hiroshi Har. Plasma/Serum Plasmalogens: Methods of Analysis and Clinical Significance. Advances in clinical chemistry. vol 70. 2016-02-02. PMID:26231485. |
in cross-sectional studies on asymptomatic, coronary artery disease, and elderly dementia individuals, we found that serum choline pls, particularly those containing oleic and linoleic acid in the sn-2 position of the glycerol backbone, may serve as reliable antiatherogenic biomarkers. |
2016-02-02 |
2023-08-13 |
Not clear |
| Seyed Khosrow Tayebati, Francesco Amenta, Daniele Tomasson. Cerebrovascular and blood-brain barrier morphology in spontaneously hypertensive rats: effect of treatment with choline alphoscerate. CNS & neurological disorders drug targets. vol 14. issue 3. 2016-02-01. PMID:25714975. |
cholinergic precursors increasing choline availability and acetylcholine synthesis/release may represent a therapeutic approach for countering cognitive impairment occurring in adult-onset dementia disorders. |
2016-02-01 |
2023-08-13 |
human |
| Enea Traini, Vincenzo Bramanti, Francesco Ament. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent. Current Alzheimer research. vol 10. issue 10. 2014-08-05. PMID:24156263. |
in clinical studies choline alphoscerate improved memory and attention impairment, as well as affective and somatic symptoms in dementia disorders. |
2014-08-05 |
2023-08-12 |
rat |
| Pier Luigi Scapicchi. Revisiting choline alphoscerate profile: a new, perspective, role in dementia? The International journal of neuroscience. vol 123. issue 7. 2014-06-26. PMID:23387341. |
revisiting choline alphoscerate profile: a new, perspective, role in dementia? |
2014-06-26 |
2023-08-12 |
Not clear |
| Seyed Amir Hossein Batouli, Perminder S Sachdev, Wei Wen, Margaret J Wright, Chao Suo, David Ames, Julian N Trollo. The heritability of brain metabolites on proton magnetic resonance spectroscopy in older individuals. NeuroImage. vol 62. issue 1. 2012-11-13. PMID:22561359. |
less is known about functional aspects of the brain, in particular biologically relevant metabolites in the brain such as those measured by proton magnetic resonance spectroscopy (((1))h mrs), n-acetyl-aspartate (naa), creatine (cr), choline (cho) and myoinositol (ml), which have been suggested as possible markers of brain aging and early dementia. |
2012-11-13 |
2023-08-12 |
Not clear |