| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Moreno-Rodríguez, Iker Bengoetxea de Tena, Jonatan Martínez-Gardeazabal, Gorka Pereira-Castelo, Alberto Llorente-Ovejero, Iván Manuel, Rafael Rodríguez-Puerta. Cannabinoid agonist WIN55,212-2 prevents scopolamine-induced impairment of spatial memory in rats. European journal of pharmacology. 2025-04-19. PMID:40252898. |
recent research demonstrates that in a rat model of dementia derived from basal forebrain cholinergic degeneration, win55,212-2, a potent cannabinoid receptor agonist, improves cognition through increased cortical choline levels. |
2025-04-19 |
2025-04-22 |
rat |
| Khanh Linh Duong, Heeyoon Jung, Hyun-Kyoung Lee, Young Jin Moon, Sang Ki Lee, Bo Ram Yang, Hwi-Yeol Yun, Jung-Woo Cha. Effect of choline alfoscerate in older adult patients with dementia: an observational study from the claims data of national health insurance. BMC geriatrics. vol 24. issue 1. 2024-11-16. PMID:39548376. |
choline alfoscerate, a cholinergic precursor with limited evidence of efficacy in dementia management, has been used for various cognitive impairments in korea. |
2024-11-16 |
2024-11-18 |
Not clear |
| Khanh Linh Duong, Heeyoon Jung, Hyun-Kyoung Lee, Young Jin Moon, Sang Ki Lee, Bo Ram Yang, Hwi-Yeol Yun, Jung-Woo Cha. Effect of choline alfoscerate in older adult patients with dementia: an observational study from the claims data of national health insurance. BMC geriatrics. vol 24. issue 1. 2024-11-16. PMID:39548376. |
thus, we aimed to describe choline alfoscerate prescription patterns and analyze their long-term effects in an older adult cohort with dementia. |
2024-11-16 |
2024-11-18 |
Not clear |
| Khanh Linh Duong, Heeyoon Jung, Hyun-Kyoung Lee, Young Jin Moon, Sang Ki Lee, Bo Ram Yang, Hwi-Yeol Yun, Jung-Woo Cha. Effect of choline alfoscerate in older adult patients with dementia: an observational study from the claims data of national health insurance. BMC geriatrics. vol 24. issue 1. 2024-11-16. PMID:39548376. |
effect of choline alfoscerate in older adult patients with dementia: an observational study from the claims data of national health insurance. |
2024-11-16 |
2024-11-18 |
Not clear |
| Jung-Min Pyun, Inho Lee, Kyungbok Lee, Min-Ho Kim, ChulHyoung Park, Hyeon-Jong Yan. Effect of Choline Alfoscerate on the Progression From Mild Cognitive Impairment to Dementia: Distributed Network Analysis of a Multicenter Korean Database Using a Common Data Model. Dementia and neurocognitive disorders. vol 23. issue 4. 2024-11-14. PMID:39512703. |
effect of choline alfoscerate on the progression from mild cognitive impairment to dementia: distributed network analysis of a multicenter korean database using a common data model. |
2024-11-14 |
2024-11-16 |
Not clear |
| Jung-Min Pyun, Inho Lee, Kyungbok Lee, Min-Ho Kim, ChulHyoung Park, Hyeon-Jong Yan. Effect of Choline Alfoscerate on the Progression From Mild Cognitive Impairment to Dementia: Distributed Network Analysis of a Multicenter Korean Database Using a Common Data Model. Dementia and neurocognitive disorders. vol 23. issue 4. 2024-11-14. PMID:39512703. |
choline alfoscerate (ca) is an acetylcholine precursor known for its beneficial effect on cognition in patient with alzheimer's disease dementia (add). |
2024-11-14 |
2024-11-16 |
Not clear |
| Ana M López-Sobaler, Viviana Loria-Kohen, María Dolores Salas-González, Laura M Bermejo, Aránzazu Aparici. [Egg components involved in cognitive function]. Nutricion hospitalaria. 2024-09-16. PMID:39279756. |
egg choline is needed for the synthesis of acetylcholine, the neurotransmitter involved in memory and learning, and also for the synthesis of phosphatidylcholine, the intake of which has been linked to better mental function and a lower risk of dementia in adults. |
2024-09-16 |
2024-09-18 |
Not clear |
| Alexandra E Cowan-Pyle, Taylor C Wallace, Kevin C Klatt, Margaret Slavin, Regan L Baile. Dietary choline and betaine intake minimally impacts rate of annualized cognitive performance throughout the menopause transition: data from the Study of Women's Health Across the Nation. Menopause (New York, N.Y.). 2024-07-30. PMID:39078663. |
dietary choline is associated with lower risk of dementia in older adults, yet this association during mid-life remains unknown. |
2024-07-30 |
2024-08-02 |
Not clear |
| Maria-Eleni Dounavi, Elizabeth McKiernan, Michael Langsen, Sarah Gregory, Graciela Muniz-Terrera, Maria Angeles Prats-Sedano, Marius Ovidiu Mada, Guy B Williams, Brian Lawlor, Lorina Naci, Clare Mackay, Ivan Koychev, Paresh Malhotra, Karen Ritchie, Craig W Ritchie, Li Su, Adam D Waldman, John T O' Brie. Investigating the brain's neurochemical profile at midlife in relation to dementia risk factors. Brain communications. vol 6. issue 3. 2024-05-23. PMID:38779354. |
a higher cardiovascular risk factors, aging, and incidence of dementia score related to higher myo-inositol, choline, total creatine and glutamate-glutamine, an effect which was mainly driven by older age and a higher body mass index. |
2024-05-23 |
2024-05-27 |
human |
| Amber Yaqub, Dina Vojinovic, Meike W Vernooij, P Eline Slagboom, Mohsen Ghanbari, Marian Beekman, Jeroen van der Grond, Thomas Hankemeier, Cornelia M van Duijn, M Arfan Ikram, Shahzad Ahma. Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia. Alzheimer's research & therapy. vol 16. issue 1. 2024-05-21. PMID:38769578. |
the gut-derived metabolite trimethylamine n-oxide (tmao) and its precursors - betaine, carnitine, choline, and deoxycarnitine - have been associated with an increased risk of cardiovascular disease, but their relation to cognition, neuroimaging markers, and dementia remains uncertain. |
2024-05-21 |
2024-05-27 |
Not clear |
| E V Ponomareva, L V Androsova, S A Krinsky, S I Gavrilov. [Efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with Mild Cognitive Impairment: a three-year prospective comparative study]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 124. issue 4. Vyp. 2. 2024-05-02. PMID:38696157. |
[efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with mild cognitive impairment: a three-year prospective comparative study]. |
2024-05-02 |
2024-05-04 |
Not clear |
| E V Ponomareva, L V Androsova, S A Krinsky, S I Gavrilov. [Efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with Mild Cognitive Impairment: a three-year prospective comparative study]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 124. issue 4. Vyp. 2. 2024-05-02. PMID:38696157. |
to study the efficacy and safety of the use of annual course therapy of choline alfoscerate (ca) as a drug potentially capable of slowing or preventing the transition of amnesic type mild cognitive impairment (amci) into clinically pronounced dementia in a three-year open comparative study, as well as to explore the possibility of predicting the preventive effect of such therapy based on a number of clinical and biological parameters. |
2024-05-02 |
2024-05-04 |
Not clear |
| Thomas A Bellio, Jessenia Y Laguna-Torres, Mary S Campion, Jay Chou, Sheila Yee, Jan K Blusztajn, Tiffany J Mellot. Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in AppNL-G-F Alzheimer's disease model mice. PloS one. vol 19. issue 2. 2024-02-06. PMID:38315685. |
together, these results demonstrate that perinatal choline supplementation is capable of preventing cognitive deficits and dampening amyloidosis in appnl-g-f mice and suggest that ensuring adequate choline consumption during early life may be a valuable method to prevent or reduce ad dementia and neuropathology. |
2024-02-06 |
2024-02-09 |
mouse |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin Fa Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. The American journal of clinical nutrition. vol 116. issue 5. 2023-05-19. PMID:37208066. |
is dietary choline intake related to dementia and alzheimer's disease risks? |
2023-05-19 |
2023-08-14 |
human |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin Fa Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. The American journal of clinical nutrition. vol 116. issue 5. 2023-05-19. PMID:37208066. |
the positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or alzheimer's disease (ad) in humans is unclear. |
2023-05-19 |
2023-08-14 |
human |
| Getu Gamo Sagaro, Enea Traini, Francesco Ament. Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683513. |
choline alphoscerate (alpha glyceryl phosphorylcholine, α-gpc) is a choline-containing phospholipid used as a medicine or nutraceutical to improve cognitive function impairment occurring in neurological conditions including adult-onset dementia disorders. |
2023-01-23 |
2023-08-14 |
Not clear |
| Paul L Wood, Randall L Woltje. Serine ether glycerophospholipids: Decrements in the frontal cortex associated with mild cognitive impairment and Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-08-25. PMID:36004004. |
the roles of these lipids in the processes involved in the development of dementia are not understood but choline and ethanolamine vinyl-ether gpl (i.e., plasmalogens) are decreased in the brains of subjects with dementia. |
2022-08-25 |
2023-08-14 |
human |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin F A Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risk: results from the Framingham Heart Study. The American journal of clinical nutrition. 2022-08-02. PMID:35918258. |
is dietary choline intake related to dementia and alzheimer's disease risk: results from the framingham heart study. |
2022-08-02 |
2023-08-14 |
human |
| Jing Yuan, Xue Liu, Chunyu Liu, Alvin F A Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacque. Is dietary choline intake related to dementia and Alzheimer's disease risk: results from the Framingham Heart Study. The American journal of clinical nutrition. 2022-08-02. PMID:35918258. |
the positive association of choline for cognition has been reported in both animal and human studies, yet the association of choline with the risk of incident dementia or alzheimer's disease (ad) in humans is unclear. |
2022-08-02 |
2023-08-14 |
human |
| Ana María López-Sobaler, Ana M Lorenzo Mora, M ª Dolores Salas González, África Peral Suárez, Aránzazu Aparicio, Rosa M ª Orteg. [Importance of choline in cognitive function]. Nutricion hospitalaria. vol 37. issue Spec No2. 2021-10-18. PMID:32993309. |
in adults and the elderly, choline intake has been associated with better performance in some cognitive functions and a lower incidence of dementia. |
2021-10-18 |
2023-08-13 |
Not clear |