| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kang-Fu Yin, Ting Chen, Xiao-Jing Gu, Zheng Jiang, Wei-Ming Su, Qing-Qing Duan, Xiang-Jin Wen, Bei Cao, Ju-Rong Li, Li-Yi Chi, Yong-Ping Che. Identification of Potential Causal Genes for Neurodegenerative Diseases by Mitochondria-Related Genome-Wide Mendelian Randomization. Molecular neurobiology. 2024-09-30. PMID:39347895. |
through the integration of summary statistics from expression quantitative trait loci (eqtl) datasets (human blood and brain tissue), mitochondrial dna copy number (mtdna-cn), and genome-wide association studies (gwas) datasets of five ndds from european ancestry, we conducted a mendelian randomization (mr) analysis to explore the potential causal relationship between mitochondrial-related genes and alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), frontotemporal dementia (ftd), and lewy body dementia (lbd). |
2024-09-30 |
2024-10-02 |
human |
| Yiming Jia, Daoxia Guo, Yi Liu, Lulu Sun, Xinyue Chang, Yu He, Mengyao Shi, Guo-Chong Chen, Yonghong Zhang, Li Hui, Zhengbao Zh. Associations between human blood metabolome and vascular dementia. Progress in neuro-psychopharmacology & biological psychiatry. 2024-09-21. PMID:39306224. |
we aimed to systematically screen the human blood metabolome to identify potential mediators of vascular dementia via a two-sample mendelian randomization (mr) design. |
2024-09-21 |
2024-09-24 |
human |
| Hong-Min Li, Cheng-Shen Qiu, Li-Ying Du, Xu-Lian Tang, Dan-Qing Liao, Zhi-Yuan Xiong, Shu-Min Lai, Hong-Xuan Huang, Ling Kuang, Bing-Yun Zhang, Zhi-Hao L. Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study. Nutrients. vol 16. issue 17. 2024-09-14. PMID:39275195. |
we assessed the causal association of circulating metabolites with dementia utilizing mendelian randomization (mr) methods. |
2024-09-14 |
2024-09-17 |
Not clear |
| Hong-Min Li, Cheng-Shen Qiu, Li-Ying Du, Xu-Lian Tang, Dan-Qing Liao, Zhi-Yuan Xiong, Shu-Min Lai, Hong-Xuan Huang, Ling Kuang, Bing-Yun Zhang, Zhi-Hao L. Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study. Nutrients. vol 16. issue 17. 2024-09-14. PMID:39275195. |
we performed univariable mr analysis to evaluate the associations of 486 metabolites with dementia, alzheimer's disease (ad), and vascular dementia (vad) risk. |
2024-09-14 |
2024-09-17 |
Not clear |
| Hong-Min Li, Cheng-Shen Qiu, Li-Ying Du, Xu-Lian Tang, Dan-Qing Liao, Zhi-Yuan Xiong, Shu-Min Lai, Hong-Xuan Huang, Ling Kuang, Bing-Yun Zhang, Zhi-Hao L. Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study. Nutrients. vol 16. issue 17. 2024-09-14. PMID:39275195. |
bayesian model averaging mr (mr-bma) analysis was further conducted to prioritize the predominant metabolites for dementia risk, which highlighted the mean diameter of hdl particles and the concentration of very large hdl particles as the predominant protective factors against dementia. |
2024-09-14 |
2024-09-17 |
Not clear |
| Yume Imahori, Chenxi Qin, Bowen Tang, Sara Häg. Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization. GeroScience. 2024-09-13. PMID:39269583. |
we conducted a comprehensive two-sample mendelian randomization (mr) study to investigate the association between various biomarkers of aging and three leading causes of nds: alzheimer's disease (ad), vascular dementia (vad), and ischemic stroke. |
2024-09-13 |
2024-09-16 |
Not clear |
| Ping Zhu, Shan Gao, Shiyang Wu, Xuan Li, Chen Huang, Yan Chen, Guiyou Li. Causal relationships between dyslexia and the risk of eight dementias. Translational psychiatry. vol 14. issue 1. 2024-09-12. PMID:39266518. |
we conducted a two-sample univariable mendelian randomization (mr) analysis to determine the causal association between dyslexia and the risk of ad, vascular dementia (vd), lewy body dementia (lbd), and frontotemporal dementia (ftd) and its four subtypes. |
2024-09-12 |
2024-09-15 |
Not clear |
| Anuja Neve, Bibha Das, Jakub Wojtowicz, Zhiyue Huang, Szofia Bullain, Michelle Watkin, Dominik Lott, Tobias Bittner, Paul Delmar, Gregory Klein, Carsten Hofmann, Geoffrey A Kerchner, Janice Smith, Monika Baudler, Paulo Fontoura, Rachelle S Dood. Long-Term Safety of Gantenerumab in Participants with Alzheimer's Disease: A Phase III, Double-Blind, and Open-Label Extension Study (Marguerite RoAD). Journal of Alzheimer's disease : JAD. 2024-08-23. PMID:39177596. |
the efficacy and safety of low-dose (105 mg or 225 mg) gantenerumab were investigated in marguerite road (mr; nct02051608), a phase iii, double-blind (db), placebo-controlled study in participants with mild alzheimer's disease (ad) dementia. |
2024-08-23 |
2024-08-25 |
human |
| Shufang Liu, Chenwei Zhang, Yukai Zhang, Zhifang Wu, Ping Wu, Shouyuan Tian, Min Zhang, Limin Lang, Li Li, Ruonan Wang, Haizhao Liu, Jingfen Zhang, Xiaolu Mao, Sijin L. Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study. Scientific reports. vol 14. issue 1. 2024-08-23. PMID:39179767. |
we conducted rigorous statistical analysis and visualization using mendelian randomization (mr) to elucidate the potential causal relationship between leukocyte counts and vascular dementia. |
2024-08-23 |
2024-08-27 |
Not clear |
| Qiuyi Chen, Chengcheng Zhang, Shiyang Wu, Yiwei He, Yuhan Liu, Libin Zheng, Bin Li, Guiyou Liu, Lu Li. Genetic evidence for causal association between migraine and dementia: a mendelian randomization study. BMC medical genomics. vol 17. issue 1. 2024-07-06. PMID:38970023. |
this study employed bidirectional two-sample mendelian randomization (mr) to investigate the potential causal relationship between migraine and dementia and its subtypes: alzheimer's disease (ad), vascular dementia (vad), frontotemporal dementia (ftd), and dementia with lewy bodies (dlb). |
2024-07-06 |
2024-07-08 |
Not clear |
| Na Gao, Hantao Chen, Xutao Guo, Xingyu Hao, Ting M. Geodesic shape regression based deep learning segmentation for assessing longitudinal hippocampal atrophy in dementia progression. NeuroImage. Clinical. vol 43. 2024-05-31. PMID:38821013. |
overall, geolongseg provides an accurate and efficient segmentation network for extracting hippocampal morphology from longitudinal mr images, which assist precise atrophy measurement of the hippocampus in early stage of dementia. |
2024-05-31 |
2024-06-02 |
Not clear |
| Zirui Wang, Xuan Yang, Haonan Li, Siqi Wang, Zhixuan Liu, Yaoyi Wang, Xingyu Zhang, Yayuan Chen, Qiang Xu, Jiayuan Xu, Zengguang Wang, Junping Wan. Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases. Translational psychiatry. vol 14. issue 1. 2024-05-28. PMID:38806463. |
the reverse mr analyses identified significantly or suggestively statistical causal effects of genetically predicted ad, lewy body dementia (lbd), and ftd on nine structural and diffusion idps. |
2024-05-28 |
2024-06-02 |
Not clear |
| Yijun Hu, Yuntao Zou, Meng Zhang, Jinglan Yan, Yuanjia Zheng, Yongjun Che. The relationship between major depressive disorder and dementia: A bidirectional two-sample Mendelian randomization study. Journal of affective disorders. 2024-03-28. PMID:38548196. |
in this study, bidirectional two-sample mendelian randomization (mr) was used to investigate the potential causal relationship between mdd and dementia via a genome-wide association study (gwas) database, containing samples from the european population. |
2024-03-28 |
2024-03-31 |
Not clear |
| Ying Xiong, Jonas Tvedt, Torbjörn Åkerstedt, Dorina Cadar, Hui-Xin Wan. Impact of sleep duration and sleep disturbances on the incidence of dementia and Alzheimer's disease: A 10-year follow-up study. Psychiatry research. vol 333. 2024-02-01. PMID:38301285. |
this study investigated the relationship between sleep measures and dementia in older adults (≥ 65) using data from the english longitudinal study of ageing (elsa) and further investigated the causal association in mendelian randomization (mr) analysis. |
2024-02-01 |
2024-02-04 |
Not clear |
| Ying Xiong, Jonas Tvedt, Torbjörn Åkerstedt, Dorina Cadar, Hui-Xin Wan. Impact of sleep duration and sleep disturbances on the incidence of dementia and Alzheimer's disease: A 10-year follow-up study. Psychiatry research. vol 333. 2024-02-01. PMID:38301285. |
the mr study did not reveal causal associations between sleep duration and dementia. |
2024-02-01 |
2024-02-04 |
Not clear |
| Pragalv Karki, Matthew C Murphy, Petrice M Cogswell, Matthew L Senjem, Jonathan Graff-Radford, Benjamin D Elder, Avital Perry, Christopher S Graffeo, Fredric B Meyer, Clifford R Jack, Richard L Ehman, John Husto. Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography. AJNR. American journal of neuroradiology. 2024-01-25. PMID:38272572. |
normal pressure hydrocephalus is a treatable cause of dementia associated with distinct mechanical property signatures in the brain as measured by mr elastography. |
2024-01-25 |
2024-01-28 |
Not clear |
| Qiaoyun Zhang, Guangheng Wu, Xiaoyu Zhang, Sheng Wang, Youxin Wan. A two-sample Mendelian randomization study of atherosclerosis and dementia. iScience. vol 26. issue 11. 2023-12-01. PMID:38026222. |
this study aimed to explore the causal effect of atherosclerosis related indicators on dementia risk based on two-sample mendelian randomization (mr) using summary statistics of genome-wide association studies (gwass). |
2023-12-01 |
2023-12-10 |
Not clear |
| Xiaomeng Xu, Ikbeom Jang, Junfang Zhang, Miao Zhang, Lijun Wang, Guanyu Ye, Aonan Zhao, Yichi Zhang, Biao Li, Jun Liu, Binyin L. Cortical gray to white matter signal intensity ratio as a sign of neurodegeneration and cognition independent of β-amyloid in dementia. Human brain mapping. 2023-11-28. PMID:38013633. |
cortical gray to white matter signal intensity ratio (gwr) measured from t1-weighted magnetic resonance (mr) images was associated with neurodegeneration and dementia. |
2023-11-28 |
2023-11-29 |
human |
| Zehan Zhang, Wenxiu Xu, Yuxiao Zheng, Congai Chen, Xiangdong Kang, Dan Chen, Fafeng Cheng, Xueqian Wan. Causal relationship between psoriasis vulgaris and dementia: Insights from Mendelian randomization analysis. Experimental dermatology. 2023-11-24. PMID:37997526. |
our study employed the mendelian randomization (mr) method to investigate the causal relationship between psoriasis vulgaris and dementia. |
2023-11-24 |
2023-11-29 |
Not clear |
| Yue Wu, Shaoyuan Lei, Dongxiao Li, Zhongzhong Li, Yingzhen Zhang, Yansu Gu. Relationship of Klotho with cognition and dementia: Results from the NHANES 2011-2014 and Mendelian randomization study. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914711. |
this study aimed to investigate the association between klotho levels and cognitive function and to determine causality between klotho and dementia using mendelian randomization (mr). |
2023-11-02 |
2023-11-08 |
Not clear |