| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Muaaz Aslam, Kang-Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E Snitz, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk. Molecular psychiatry. 2023-09-04. PMID:37666928. |
lower plasma apoe level has also been suggested to be a risk factor for incident dementia. |
2023-09-04 |
2023-09-07 |
human |
| M Muaaz Aslam, Kang-Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E Snitz, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk. Molecular psychiatry. 2023-09-04. PMID:37666928. |
this study aimed to identify new genetic variants affecting plasma apoe level as well as to test if baseline apoe level is associated with cognitive function and incident dementia in a longitudinally followed cohort of the ginkgo evaluation of memory (gem) study. |
2023-09-04 |
2023-09-07 |
human |
| M Muaaz Aslam, Kang-Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E Snitz, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk. Molecular psychiatry. 2023-09-04. PMID:37666928. |
lower apoe concentration was associated with worse cognitive function, but not with incident dementia. |
2023-09-04 |
2023-09-07 |
human |
| Stephanie Langella, N Gil Barksdale, Daniel Vasquez, David Aguillon, Yinghua Chen, Yi Su, Natalia Acosta-Baena, Juliana Acosta-Uribe, Ana Y Baena, Gloria Garcia-Ospina, Margarita Giraldo-Chica, Victoria Tirado, Claudia Mu\\xc3\\xb1oz, Silvia R\\xc3\\xados-Romenets, Claudia Guzman-Mart\\xc3\\xadnez, Gabriel Oliveira, Hyun-Sik Yang, Clara Vila-Castelar, Jeremy J Pruzin, Valentina Ghisays, Joseph F Arboleda-Velasquez, Kenneth S Kosik, Eric M Reiman, Francisco Lopera, Yakeel T Quiro. Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-08-23. PMID:37612284. |
although apolipoprotein e (apoe) genotype and educational attainment both influence dementia onset in sporadic ad, evidence for these effects in adad is limited. |
2023-08-23 |
2023-09-07 |
Not clear |
| Jiachen Chen, Margaret F Doyle, Yuan Fang, Jesse Mez, Paul K Crane, Phoebe Scollard, Claudia L Satizabal, Michael L Alosco, Wei Qiao Qiu, Joanne M Murabito, Kathryn L Lunett. Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort. Aging cell. 2023-08-16. PMID:37584418. |
cross-sectional associations of the biomarkers with cognitive domain scores (n\xe2\x80\x89=\xe2\x80\x89708, 53% female, 22% apolipoprotein e (apoe) \xce\xb54 carriers, 15% apoe \xce\xb52 carriers, mean age 61) and incident all-cause and ad dementia during up to 20\xe2\x80\x89years of follow-up were tested. |
2023-08-16 |
2023-09-07 |
human |
| Katrine L Rasmussen, Jiao Luo, B\\xc3\\xb8rge G Nordestgaard, Anne Tybj\\xc3\\xa6rg-Hansen, Ruth Frikke-Schmid. APOE and vascular disease: Sequencing and genotyping in general population cohorts. Atherosclerosis. 2023-08-16. PMID:37586954. |
the apolipoprotein e(apoe) \xcf\xb52/\xcf\xb53/\xcf\xb54 polymorphism plays a central role in lipid metabolism, vascular disease and dementia. |
2023-08-16 |
2023-09-07 |
Not clear |
| Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P De Deyn, Martina Luchetti, Angelina R Suti. Neuroticism and white matter hyperintensities. Journal of psychiatric research. vol 165. 2023-07-28. PMID:37506413. |
the association was not moderated by age, sex, college education, deprivation index, or apoe e4 genotype, and remained unchanged in sensitivity analyses that excluded individuals with dementia or those younger than 65. |
2023-07-28 |
2023-08-14 |
human |
| Martin L\\xc3\\xb6vd\\xc3\\xa9n, Amos Pagin, David Bartr\\xc3\\xa9s-Faz, Carl-Johan Boraxbekk, Andreas M Brandmaier, Naiara Demnitz, Christian A Drevon, Klaus P Ebmeier, Anders M Fjell, Paolo Ghisletta, Tetiana Gorbach, Ulman Lindenberger, Anna Plachti, Kristine B Walhovd, Lars Nyber. No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging. Aging brain. vol 4. 2023-07-17. PMID:37457634. |
restricting the sample to individuals with elevated genetic risk for dementia (apoe \xce\xb54 carriers) did not change these results. |
2023-07-17 |
2023-08-14 |
Not clear |
| Michelle M Dunk, Jie Li, Simin Liu, Ramon Casanova, Jiu-Chiuan Chen, Mark A Espeland, Kathleen M Hayden, JoAnn E Manson, Stephen R Rapp, Aladdin H Shadyab, Linda G Snetselaar, Linda Van Horn, Robert Wild, Ira Driscol. Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-13. PMID:37438877. |
associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by apoe genotype. |
2023-07-13 |
2023-08-14 |
Not clear |
| Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Jennifer C Howell, William T Hu, Kim Kultima, Henrietta M Nielse. Plasma apolipoprotein E levels, isoform composition, and dimer profile in relation to plasma lipids in racially diverse patients with Alzheimer's disease and mild cognitive impairment. Alzheimer's research & therapy. vol 15. issue 1. 2023-07-03. PMID:37400888. |
previous studies reported lower plasma apolipoprotein e (apoe) levels in nhw apoe\xce\xb54-carriers compared to non-carriers, and low plasma apoe levels were directly associated with an increased risk of ad and all dementia. |
2023-07-03 |
2023-08-14 |
human |
| Rui Zhou, Hao-Wen Chen, Fu-Rong Li, Qi Zhong, Yi-Ning Huang, Xian-Bo W. "Life's Essential 8" Cardiovascular Health and Dementia Risk, Cognition, and Neuroimaging Markers of Brain Health. Journal of the American Medical Directors Association. 2023-06-27. PMID:37369360. |
to evaluate associations of life's essential 8 (le8) score, the recently updated metric for promoting cardiovascular health (cvh), with the risk of incident dementia and its subtypes, cognition, and neuroimaging outcomes and to determine whether these associations differ among apolipoprotein e (apoe)-\xce\xb54 genotypes. |
2023-06-27 |
2023-08-14 |
Not clear |
| Yuda Huang, Yongzhi Shan, Wen Qin, Guoguang Zha. Apolipoprotein E \\xce\\xb54 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment. Frontiers in aging neuroscience. vol 15. 2023-06-16. PMID:37323144. |
however, previous research has not directly outlined the modulation of apoe on the trajectory of cerebral atrophy with aging during the conversion from cognitive normal (cn) to dementia (cn2d). |
2023-06-16 |
2023-08-14 |
Not clear |
| Matthew Amontree, Samantha Deasy, R Scott Turner, Katherine Conan. Matrix disequilibrium in Alzheimer's disease and conditions that increase Alzheimer's disease risk. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304012. |
two of the greatest non-modifiable risk factors for development of ad (aside from autosomal dominant familial ad gene mutations) are aging and apoe status, and two of the greatest modifiable risk factors for ad and related dementias are untreated major depressive disorder (mdd) and obesity. |
2023-06-12 |
2023-08-14 |
Not clear |
| Huu-Hien Huynh, Kellie Kuch, Allen Orquillas, Katrina Forrest, Lili Barahona-Carrillo, Dirk Keene, Victor W Henderson, Anthony D Wagner, Kathleen L Poston, Thomas J Montine, Amy Lin, Lu Tian, Michael J MacCoss, Michelle A Emrick, Andrew N Hoofnagl. Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid. Clinical chemistry. 2023-06-06. PMID:37279935. |
thus, the concentration of apolipoprotein e (apoe) isoforms in cerebrospinal fluid (csf) could be altered in dementia. |
2023-06-06 |
2023-08-14 |
Not clear |
| Nandakumar Nagaraja, Steven DeKosky, Ranjan Duara, Lan Kong, Wei-En Wang, David Vaillancourt, Mehmet Albayra. Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer's disease. NeuroImage. Clinical. vol 38. 2023-05-28. PMID:37245492. |
in subjects with alzheimer's disease (ad), we assessed characteristic features and amounts of wmh, lacunes, and epvs in four caa categories (no, mild, moderate and severe caa) and correlated these with clinical dementia rating sum of boxes (cdrsb) score, apoe genotype, and neuropathological changes at autopsy. |
2023-05-28 |
2023-08-14 |
human |
| Jiangtao Feng, Qi Wang, Yuan Zhan. Ideal vitamin D and handgrip strength counteracts the risk effect of APOE genotype on dementia: a population-based longitudinal study. Journal of translational medicine. vol 21. issue 1. 2023-05-28. PMID:37246226. |
ideal vitamin d and handgrip strength counteracts the risk effect of apoe genotype on dementia: a population-based longitudinal study. |
2023-05-28 |
2023-08-14 |
Not clear |
| Jiangtao Feng, Qi Wang, Yuan Zhan. Ideal vitamin D and handgrip strength counteracts the risk effect of APOE genotype on dementia: a population-based longitudinal study. Journal of translational medicine. vol 21. issue 1. 2023-05-28. PMID:37246226. |
higher vitamin d concentrations and grip strength contribute to lower individual-level risk of dementia, while apolipoprotein 4 (apoe e4) genotype carries increases dementia risk, but whether combination of ideal vitamin d and grip strength counteracts the risk effect of dementia related to apoe e4 genotype remains unclear. |
2023-05-28 |
2023-08-14 |
Not clear |
| Jiangtao Feng, Qi Wang, Yuan Zhan. Ideal vitamin D and handgrip strength counteracts the risk effect of APOE genotype on dementia: a population-based longitudinal study. Journal of translational medicine. vol 21. issue 1. 2023-05-28. PMID:37246226. |
we aimed to investigate the interactions between vitamin d/grip strength and apoe e4 genotype and their association with dementia. |
2023-05-28 |
2023-08-14 |
Not clear |
| Paolo Abondio, Francesco Bruno, Donata Luisell. Apolipoprotein E (APOE) Haplotypes in Healthy Subjects from Worldwide Macroareas: A Population Genetics Perspective for Cardiovascular Disease, Neurodegeneration, and Dementia. Current issues in molecular biology. vol 45. issue 4. 2023-05-16. PMID:37185708. |
apolipoprotein e (apoe) haplotypes in healthy subjects from worldwide macroareas: a population genetics perspective for cardiovascular disease, neurodegeneration, and dementia. |
2023-05-16 |
2023-08-14 |
human |
| Lenique K L Huggins, Se Hee Min, Samantha Kaplan, Jingkai Wei, Kathleen Welsh-Bohmer, Hanzhang X. Meta-Analysis of Variations in Association between APOE \\xc9\\x9b4 and Alzheimer's Disease and Related Dementias Across Hispanic Regions of Origin. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182874. |
meta-analysis of variations in association between apoe \xc9\x9b4 and alzheimer's disease and related dementias across hispanic regions of origin. |
2023-05-14 |
2023-08-14 |
Not clear |