| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Li, Shaowei Hou, Feixiang Li, Siwen Long, Yue Yang, Yize Li, Lina Zhao, Yonghao Y. Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1. Brain research bulletin. vol 211. 2024-04-12. PMID:38608544. |
preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing eeg delta-wave activity and lfp theta oscillation in hippocampal ca1. |
2024-04-12 |
2024-04-15 |
mouse |
| Lan Fu, Lin-Na Guan, Hongye Zu. Long period changes of hippocampal diffusion kurtosis imaging and its correlation with cognitive dysfunction after incomplete cerebral ischemia-reperfusion in rats. Experimental brain research. 2023-10-25. PMID:37878109. |
this study aims to summarize the changes of functional diffusion kurtosis imaging (dki) parameters in the bilateral hippocampal ca1 region of the hemorrhagic shock reperfusion (hsr) model of rats and their correlation with cognitive dysfunction. |
2023-10-25 |
2023-11-08 |
rat |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
caloric restriction can ameliorate postoperative cognitive dysfunction by upregulating the expression of sirt1, mecp2 and bdnf in the hippocampal ca1 region of aged c57bl/6 mice. |
2023-03-29 |
2023-08-14 |
mouse |
| Yuanyuan Chen, Chuan Yang, Mi Zou, Dan Wang, Ruilin Sheng, Meng Zhan, Qi Chen, Wenqin Yang, Xiao Liu, Shijun X. Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: A mechanism of alpinetin attenuated aging-associated cognitive impairment. Phytotherapy research : PTR. 2023-02-11. PMID:36772986. |
our data indicated that alpinetin significantly alleviated cognitive dysfunction and neuronal damage in the ca1 and ca3 regions of d-gal-treated mice. |
2023-02-11 |
2023-08-14 |
mouse |
| Xupeng Wang, Yanan Li, Juan Zhao, Jiaxu Yu, Qi Zhang, Fang Xu, Yahui Zhang, Qi Zhou, Chunping Yin, Zhiyong Hou, Qiujun Wan. Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36437995. |
we used golgi staining and neuroelectrophysiological techniques to detect structurally and functionally impaired synaptic plasticity in hippocampal ca1 region of postoperative cognitive dysfunction aged mice, respectively. |
2022-11-28 |
2023-08-14 |
mouse |
| Xupeng Wang, Yanan Li, Juan Zhao, Jiaxu Yu, Qi Zhang, Fang Xu, Yahui Zhang, Qi Zhou, Chunping Yin, Zhiyong Hou, Qiujun Wan. Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36437995. |
activation of astrocyte gq pathway in hippocampal ca1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice. |
2022-11-28 |
2023-08-14 |
mouse |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Xiaojiao Ma, Oumei Cheng, Qingsong Jiang, Junxia Yang, Huan Xiao, Hongmei Qi. Activation of ephrinb1/EPHB2/MAP-2/NMDAR Mediates Hippocampal Neurogenesis Promoted by Transcranial Direct Current Stimulation in Cerebral-Ischemic Mice. Neuromolecular medicine. vol 23. issue 4. 2021-12-02. PMID:33782855. |
compared with the sham mice, the model mice showed significant neuronal damage in the hippocampal ca1 region (p < 0.01), cognitive dysfunction (p < 0.01), and endogenous hippocampal neurogenesis (p < 0.01). |
2021-12-02 |
2023-08-13 |
mouse |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. Tamoxifen offers long-term neuroprotection after hippocampal silent infarct in male rats. Hormones and behavior. vol 136. 2021-11-29. PMID:34749277. |
we found that tamoxifen protected against the si-induced cognitive dysfunction on the hippocampal-dependent, place recognition task, cell and er loss, and increased apoptosis and gliosis in the ca1. |
2021-11-29 |
2023-08-13 |
rat |
| Suvi R K Hokkanen, Mia Kero, Karri Kaivola, Sally Hunter, Hannah A D Keage, Anna Kiviharju, Anna Raunio, Pentti J Tienari, Anders Paetau, Fiona E Matthews, Jane Fleming, Caroline Graff, Tuomo M Polvikoski, Liisa Myllykangas, Carol Brayn. Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31376286. |
limbic-predominant age-related tar-dna-binding protein-43 (tdp-43) encephalopathy with hippocampal sclerosis pathology (late-nc + hs) is a neurodegenerative disorder characterized by severe hippocampal ca1 neuron loss and tdp-43-pathology, leading to cognitive dysfunction and dementia. |
2021-01-13 |
2023-08-13 |
Not clear |
| Sean Johnson, David F Wozniak, S Ima. CA1 NPJ aging and mechanisms of disease. vol 4. 2020-09-30. PMID:30416740. |
ca1 cognitive dysfunction is one of the most concerning outcomes in global population aging. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lifeng Zheng, Mei Yu, Rui Lin, Yunxuan Wang, Zhan Zhuo, Ning Cheng, Mengzhen Wang, Yongqiang Tang, Liping Wang, Sheng-Tao Ho. Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity. Nature communications. vol 11. issue 1. 2020-08-24. PMID:32541656. |
these results support a causal relationship between ca1 slow gamma and cognitive dysfunctions in the ischemic brain. |
2020-08-24 |
2023-08-13 |
mouse |
| Jing Zhong, Chenyue Guo, Wenting Hou, Na Shen, Changhong Mia. Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats. Life sciences. vol 235. 2019-11-08. PMID:31476310. |
to investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (mfhas1) on cognitive dysfunction, the expression of tumor necrosis factor-α (tnf-α), interleukin (il)-1β and amyloid β peptide (aβ) in the hippocampus, as well as dendritic pathology in the hippocampal ca1 region in sepsis-associated encephalopathy (sae) rats. |
2019-11-08 |
2023-08-13 |
rat |
| Zi-Ai Zhao, Ping Li, Shi-Yang Ye, Ya-Lei Ning, Hao Wang, Yan Peng, Nan Yang, Yan Zhao, Zhuo-Hang Zhang, Jiang-Fan Chen, Yuan-Guo Zho. Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28533515. |
perivascular aqp4 dysregulation in the hippocampal ca1 area after traumatic brain injury is alleviated by adenosine a traumatic brain injury (tbi) can induce cognitive dysfunction due to the regional accumulation of hyperphosphorylated tau protein (p-tau). |
2018-12-11 |
2023-08-13 |
Not clear |
| Hui Zhang, Li Ma, Yan-Ling Yin, Lian-Qiang Dong, Gang-Ge Cheng, Ya-Qun Ma, Yun-Feng Li, Bai-Nan X. Over-expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction caused by lipopolysaccharide in mice. Brain research. vol 1646. 2017-07-20. PMID:27265418. |
over-expression of tspo in the hippocampal ca1 area alleviates cognitive dysfunction caused by lipopolysaccharide in mice. |
2017-07-20 |
2023-08-13 |
mouse |
| Soheila Pourkhodadad, Masoud Alirezaei, Mehrnoush Moghaddasi, Hassan Ahmadvand, Manizheh Karami, Bahram Delfan, Zahra Khanipou. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. The journal of physiological sciences : JPS. vol 66. issue 5. 2017-05-09. PMID:26892487. |
thereafter, colchicine (15 μg/rat) was administered into the ca1 area of the hippocampus to induce cognitive dysfunction. |
2017-05-09 |
2023-08-13 |
rat |
| Soheila Pourkhodadad, Masoud Alirezaei, Mehrnoush Moghaddasi, Hassan Ahmadvand, Manizheh Karami, Bahram Delfan, Zahra Khanipou. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. The journal of physiological sciences : JPS. vol 66. issue 5. 2017-05-09. PMID:26892487. |
neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal ca1 area in rats. |
2017-05-09 |
2023-08-13 |
rat |
| Soheila Pourkhodadad, Masoud Alirezaei, Mehrnoush Moghaddasi, Hassan Ahmadvand, Manizheh Karami, Bahram Delfan, Zahra Khanipou. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. The journal of physiological sciences : JPS. vol 66. issue 5. 2017-05-09. PMID:26892487. |
the purpose of this study was to evaluate pretreatment effects of oleuropein on oxidative status and cognitive dysfunction induced by colchicine in the hippocampal ca1 area. |
2017-05-09 |
2023-08-13 |
rat |
| Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Khadije Esmaeilpour, Vahid Sheiban. Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure. European journal of pharmacology. vol 786. 2017-03-10. PMID:27235295. |
the major objective of this study was to investigate the probable effects of genistein (one of the most important soy phytoestrogens-spes) on seizure-induced cognitive dysfunction, hippocampal early long-term potentiation (e-ltp) impairment and morphological damage to ca1 neurons in ovariectomized (ovx) rats. |
2017-03-10 |
2023-08-13 |
rat |
| Natalie Matosin, Francesca Fernandez-Enright, Jeremy S Lum, Martin Engel, Jessica L Andrews, Nils C Gassen, Klaus V Wagner, Mathias V Schmidt, Kelly A Newel. Molecular evidence of synaptic pathology in the CA1 region in schizophrenia. NPJ schizophrenia. vol 2. 2016-07-19. PMID:27430010. |
these findings support the presence of extensive molecular abnormalities to psd95 and several of its associated proteins in the ca1 region in schizophrenia, offering a small but significant step toward understanding how proteins in the psd are altered in the schizophrenia brain, and their relevance to overall hippocampal and cognitive dysfunction in the illness. |
2016-07-19 |
2023-08-13 |
human |