| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manjeet Kumar, Sidharth Mehan, Aakash Kumar, Tarun Sharma, Zuber Khan, Aarti Tiwari, Ghanshyam Das Gupta, Acharan S Narul. Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis. Brain research. 2024-10-09. PMID:39384128. |
pathologically, autism is linked to mitochondrial dysfunction, oxidative stress, neuroinflammation, and neurotransmitter imbalances involving gaba, glutamate, dopamine, and oxytocin. |
2024-10-09 |
2024-10-12 |
rat |
| Z Hussein, A Alzamil. MITOCHONDRIAL VITIATION CONGRUENTLY APTLY WITH AUTISM SPECTRUM DISORDER. Georgian medical news. issue 349. 2024-07-04. PMID:38963220. |
aim - measuring and evaluating the levels of mitochondrial markers; including glutamate oxaloacetate transaminase (got), glutamate pyruvate transaminase (gpt), malate dehydrogenase, and pyruvate kinase) in the autistic group and knowing the possibility of using these markers to diagnose children with autism spectrum disorder. |
2024-07-04 |
2024-07-10 |
Not clear |
| Kaspar Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Genevieve Konopka, Robert Green. Sleep need driven oscillation of glutamatergic synaptic phenotype. bioRxiv : the preprint server for biology. 2024-02-19. PMID:38370691. |
the degs are enriched for a functional group of synaptic shaping cellular components (sscs) controling glutamate synapse phenotype, overlap with autism risk genes and are primarily observed in a subtype of excitatory pyramidal neurons that project intra-telencephalically (exit neurons). |
2024-02-19 |
2024-02-21 |
Not clear |
| Amjad Mhanna, Nafiza Martini, Ghefar Hmaydoosh, George Hamwi, Mulham Jarjanazi, Ghaith Zaifah, Reem Kazzazo, Aya Haji Mohamad, Zuheir Alshehab. The correlation between gut microbiota and both neurotransmitters and mental disorders: A narrative review. Medicine. vol 103. issue 5. 2024-02-02. PMID:38306525. |
this review aims to summarize the modulation role of the gut microbiota in 4 prominent neurotransmitters (tryptophan and serotonergic system, dopamine, gamma-aminobutyric acid, and glutamate), as well as its association with 4 psychiatric disorders (schizophrenia, depression, anxiety disorders, and autism spectrum disorder). |
2024-02-02 |
2024-02-05 |
Not clear |
| Zohreh Soltani, Marjan Shariatpanahi, Mehdi Aghsami, Hamid Owliaey, Afshin Kheradman. Investigating the effect of exposure to monosodium glutamate during pregnancy on development of autism in male rat offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-01-20. PMID:38244665. |
investigating the effect of exposure to monosodium glutamate during pregnancy on development of autism in male rat offspring. |
2024-01-20 |
2024-01-23 |
rat |
| Zohreh Soltani, Marjan Shariatpanahi, Mehdi Aghsami, Hamid Owliaey, Afshin Kheradman. Investigating the effect of exposure to monosodium glutamate during pregnancy on development of autism in male rat offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-01-20. PMID:38244665. |
in present study, we investigated the relationship between the pregnancy exposure to monosodium glutamate (msg) and autism development in male offspring of rats. |
2024-01-20 |
2024-01-23 |
rat |
| Duanghathai Pasanta, David J White, Jason L He, Talitha C Ford, Nicolaas A Put. GABA and glutamate response to social processing: a functional MRS feasibility study. NMR in biomedicine. 2023-12-28. PMID:38154459. |
autism) is associated with differences in excitation and inhibition, through changes in the levels of glutamate and gamma-aminobutyric acid (gaba). |
2023-12-28 |
2023-12-31 |
Not clear |
| Nina-Francesca Parrella, Aron T Hill, Lillian M Dipnall, Yuk Jing Loke, Peter G Enticott, Talitha C For. Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review. Journal of psychiatric research. vol 169. 2023-11-28. PMID:38016393. |
many of the social processing difficulties experienced in autism have been linked to higher levels of the excitatory neurotransmitter glutamate and/or lower levels of inhibitory gaba. |
2023-11-28 |
2023-12-07 |
Not clear |
| Allegra J Johnson, Eric Shankland, Todd Richards, Neva Corrigan, Dennis Shusterman, Richard Edden, Annette Estes, Tanya St John, Stephen Dager, Natalia M Kleinhan. Relationships between GABA, glutamate, and GABA/glutamate and social and olfactory processing in children with autism spectrum disorder. Psychiatry research. Neuroimaging. vol 336. 2023-11-13. PMID:37956467. |
relationships between gaba, glutamate, and gaba/glutamate and social and olfactory processing in children with autism spectrum disorder. |
2023-11-13 |
2023-11-20 |
human |
| Allegra J Johnson, Eric Shankland, Todd Richards, Neva Corrigan, Dennis Shusterman, Richard Edden, Annette Estes, Tanya St John, Stephen Dager, Natalia M Kleinhan. Relationships between GABA, glutamate, and GABA/glutamate and social and olfactory processing in children with autism spectrum disorder. Psychiatry research. Neuroimaging. vol 336. 2023-11-13. PMID:37956467. |
theories of altered inhibitory/excitatory signaling in autism spectrum disorder (asd) suggest that gamma amino butyric acid (gaba) and glutamate (glu) abnormalities may underlie social and sensory challenges in asd. |
2023-11-13 |
2023-11-20 |
human |
| Jun Liu, Jing Yan, Fei Qu, Weiming Mo, Hong Yu, Pingfang Hu, Zengyu Zhan. A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum. Metabolic brain disease. 2023-08-14. PMID:37578654. |
imbalanced glutamate signaling has been implicated in the development of autism spectrum disorder (asd). |
2023-08-14 |
2023-08-16 |
Not clear |
| Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y Aoki, Haruhisa Ohta, Ryu-Ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuch. Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468523. |
increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism. |
2023-07-19 |
2023-08-14 |
Not clear |
| Mohamed Z Habib, Esraa M Elnahas, Yasmin M Aboul-Ela, Mai A Ebeid, Marwa Tarek, Doaa R Sadek, Eman A Negm, Dina A Abdelhakam, Sawsan Aboul-Fotou. Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing. European journal of pharmacology. 2023-07-17. PMID:37460052. |
risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: role of adar2 in ampa glua2 rna editing. |
2023-07-17 |
2023-08-14 |
rat |
| Luisa Di Menna, Rosamaria Orlando, Giovanna D'Errico, Roxana Paula Ginerete, Agata Machaczka, Carmela M Bonaccorso, Andrea Arena, Michela Spatuzza, Roberta Celli, Marika Alborghetti, Eleonora Ciocca, Anna Rita Zuena, Maria Rosaria Scioli, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Maria Vincenza Catani. Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism. Neuropharmacology. 2023-07-01. PMID:37392820. |
blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism. |
2023-07-01 |
2023-08-14 |
mouse |
| Chenhui Ji, Yalin Tang, Yanyan Zhang, Xiaoyan Huang, Congcong Li, Yuhong Yang, Qihui Wu, Xiaohuan Xia, Qingyuan Cai, Xin-Rui Qi, Jialin C Zhen. Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors. Cell reports. vol 42. issue 7. 2023-06-29. PMID:37384529. |
an abnormal glutamate signaling pathway has been proposed in the mechanisms of autism spectrum disorder (asd). |
2023-06-29 |
2023-08-14 |
mouse |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
memantine/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal creb/bdnf signaling and glutamate homeostasis. |
2023-03-15 |
2023-08-14 |
human |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
excitatory/inhibitory imbalance in autism: the role of glutamate and gaba gene-sets in symptoms and cortical brain structure. |
2023-01-21 |
2023-08-14 |
human |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
using competitive gene-set analyses, we investigated whether aggregated genetic variation in glutamate and gaba gene-sets could be associated with behavioral measures of autism symptoms and brain structural variation. |
2023-01-21 |
2023-08-14 |
human |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
the glutamate gene-set was associated with all autism symptom severity scores on the autism diagnostic observation schedule-2 (ados-2) and the autism diagnostic interview-revised (adi-r) within the autistic group. |
2023-01-21 |
2023-08-14 |
human |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
our results suggest complex relationships between e/i related genetics and autism symptom profiles as well as brain structure alterations, where there may be differential roles for glutamate and gaba. |
2023-01-21 |
2023-08-14 |
human |