| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susan G Dorsey, Evelina Mocci, Malcolm V Lane, Bruce K Kruege. Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autism. bioRxiv : the preprint server for biology. 2024-12-10. PMID:37205520. |
expression of genes associated with neu-rodevelopmental disorders (ndds) such as autism as well as neurogenesis, axon growth and syn-aptogenesis, gabaergic, glutaminergic and dopaminergic synaptic transmission, perineuronal nets, and circadian rhythms was dysregulated by vpa. |
2024-12-10 |
2024-12-12 |
mouse |
| Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajd. Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder. Molecules (Basel, Switzerland). vol 29. issue 22. 2024-11-27. PMID:39598660. |
while the etiology and pathophysiology of autism spectrum disorder are still not fully understood, recent studies have suggested that wide alterations in the gabaergic, glutamatergic, cholinergic, and serotonergic systems play a key role in its development and progression. |
2024-11-27 |
2024-11-29 |
Not clear |
| Claire E Cho, Dahee Jung, Reesha R Pate. Sleepless nights and social plights: medial septum GABAergic hyperactivity in a neuroligin 3-deficient autism model. The Journal of clinical investigation. vol 134. issue 19. 2024-10-01. PMID:39352378. |
sleepless nights and social plights: medial septum gabaergic hyperactivity in a neuroligin 3-deficient autism model. |
2024-10-01 |
2024-10-03 |
Not clear |
| b' Zuzana Ba\\xc4\\x8dov\\xc3\\xa1, Bohumila Jurkovi\\xc4\\x8dov\\xc3\\xa1-Tarabov\\xc3\\xa1, Tom\\xc3\\xa1\\xc5\\xa1 Havr\\xc3\\xa1nek, Denisa Mihalj, Veronika Borb\\xc3\\xa9lyov\\xc3\\xa1, Zdenko Pirnik, Boris Mravec, Daniela Ostatn\\xc3\\xadkov\\xc3\\xa1, J\\xc3\\xa1n Bako\\xc5\\xa. Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons. Molecular brain. vol 17. issue 1. 2024-09-28. PMID:39334399.' |
therefore, investigating the morphology and functional roles of gabaergic neurons within dopaminergic projection areas could elucidate the underlying etiology of autism. |
2024-09-28 |
2024-10-01 |
mouse |
| Lara Eid, Ludmilla Lokmane, Praveen K Raju, Samuel Boris Tene Tadoum, Xiao Jiang, Karolanne Toulouse, Alexis Lupien-Meilleur, François Charron-Ligez, Asmaa Toumi, Stéphanie Backer, Mathieu Lachance, Marisol Lavertu-Jolin, Marie Montseny, Jean-Claude Lacaille, Evelyne Bloch-Gallego, Elsa Rossigno. Both GEF domains of the autism and developmental epileptic encephalopathy-associated Trio protein are required for proper tangential migration of GABAergic interneurons. Molecular psychiatry. 2024-09-19. PMID:39300136. |
both gef domains of the autism and developmental epileptic encephalopathy-associated trio protein are required for proper tangential migration of gabaergic interneurons. |
2024-09-19 |
2024-09-22 |
Not clear |
| A A Nascimento, D Pereira-Figueiredo, V P Borges-Martins, R C Kubrusly, K C Calaz. GABAergic system and chloride cotransporters as potential therapeutic targets to mitigate cell death in ischemia. Journal of neuroscience research. vol 102. issue 5. 2024-05-29. PMID:38808645. |
dysregulation of gabaergic signaling, particularly involving the cotransporters nkcc1 and kcc2, has been implicated in various pathologies, including epilepsy, schizophrenia, autism spectrum disorder, down syndrome, and ischemia. |
2024-05-29 |
2024-06-02 |
Not clear |
| Tomas Havranek, Zuzana Bacova, Jan Bako. Oxytocin, GABA, and dopamine interplay in autism. Endocrine regulations. vol 58. issue 1. 2024-04-24. PMID:38656256. |
special attention has been paid to the results describing a reduced expression of inhibitory gabaergic markers in the brain in the context of dopaminergic areas in various models of autism. |
2024-04-24 |
2024-04-28 |
Not clear |
| Tomas Havranek, Zuzana Bacova, Jan Bako. Oxytocin, GABA, and dopamine interplay in autism. Endocrine regulations. vol 58. issue 1. 2024-04-24. PMID:38656256. |
it is presumed that the altered gabaergic neurotransmission, due to the absence or dysfunction of oxytocin at certain developmental stages, disinhibits the dopaminergic signaling and contributes to the autism symptoms. |
2024-04-24 |
2024-04-28 |
Not clear |
| Qiyun Huang, Claire L Ellis, Shaun M Leo, Hester Velthuis, Andreia C Pereira, Mihail Dimitrov, Francesca M Ponteduro, Nichol M L Wong, Eileen Daly, Declan G M Murphy, Omar A Mahroo, Gráinne M McAlona. Retinal GABAergic alterations in adults with autism spectrum disorder. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-11. PMID:38467434. |
retinal gabaergic alterations in adults with autism spectrum disorder. |
2024-03-11 |
2024-03-14 |
human |
| Brendan Gillespie, Sandesh Panthi, Suresh Sundram, Rachel A Hil. The Impact of Maternal Immune Activation on GABAergic Interneuron Development: A Systematic Review of Rodent Studies and their Translational Implications. Neuroscience and biobehavioral reviews. 2023-12-02. PMID:38042358. |
mothers exposed to infections during pregnancy disproportionally birth children who develop autism and schizophrenia, disorders associated with altered gabaergic function. |
2023-12-02 |
2023-12-10 |
Not clear |
| Nina-Francesca Parrella, Aron T Hill, Lillian M Dipnall, Yuk Jing Loke, Peter G Enticott, Talitha C For. Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review. Journal of psychiatric research. vol 169. 2023-11-28. PMID:38016393. |
the primary inhibitory neurotransmitter γ-aminobutyric acid (gaba) has a prominent role in regulating neural development and function, with disruption to gabaergic signalling linked to behavioural phenotypes associated with neurodevelopmental disorders, particularly autism. |
2023-11-28 |
2023-12-07 |
Not clear |
| Qiyun Huang, Hester Velthuis, Andreia C Pereira, Jumana Ahmad, Samuel F Cooke, Claire L Ellis, Francesca M Ponteduro, Nicolaas A J Puts, Mihail Dimitrov, Dafnis Batalle, Nichol M L Wong, Lukasz Kowalewski, Glynis Ivin, Eileen Daly, Declan G M Murphy, Gráinne M McAlona. Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder. Translational psychiatry. vol 13. issue 1. 2023-10-20. PMID:37852957. |
exploratory evidence for differences in gabaergic regulation of auditory processing in autism spectrum disorder. |
2023-10-20 |
2023-11-08 |
Not clear |
| Leonardo Nardi, Stuti Chhabra, Petra Leukel, Dilja Krueger-Burg, Clemens J Sommer, Michael J Schmeisse. Neuroanatomical changes of ionotropic glutamatergic and GABAergic receptor densities in male mice modeling idiopathic and syndromic autism spectrum disorder. Frontiers in psychiatry. vol 14. 2023-08-07. PMID:37547211. |
neuroanatomical changes of ionotropic glutamatergic and gabaergic receptor densities in male mice modeling idiopathic and syndromic autism spectrum disorder. |
2023-08-07 |
2023-08-14 |
mouse |
| Ciara J Molloy, Jennifer Cooke, Nicholas J F Gatford, Alejandro Rivera-Olvera, Sahar Avazzadeh, Judith R Homberg, Joanes Grandjean, Cathy Fernandes, Sanbing Shen, Eva Loth, Deepak P Srivastava, Louise Gallaghe. Bridging the translational gap: what can synaptopathies tell us about autism? Frontiers in molecular neuroscience. vol 16. 2023-07-13. PMID:37441676. |
altered synaptic biology is suggested by both preclinical and clinical studies in autism based on evidence of differences in early brain structural development and altered glutamatergic and gabaergic neurotransmission potentially perturbing excitatory and inhibitory balance. |
2023-07-13 |
2023-08-14 |
human |
| Janusz Frackowiak, Bozena Mazur-Koleck. Intraneuronal accumulation of amyloid-β peptides as the pathomechanism linking autism and its co-morbidities: epilepsy and self-injurious behavior - the hypothesis. Frontiers in molecular neuroscience. vol 16. 2023-06-12. PMID:37305553. |
autism spectrum disorder (asd) is associated with enhanced processing of amyloid-β precursor protein (app) by secretase-α, higher blood levels of sappα and intraneuronal accumulation of n-terminally truncated aβ peptides in the brain cortex - mainly in the gabaergic neurons expressing parvalbumin - and subcortical structures. |
2023-06-12 |
2023-08-14 |
Not clear |
| Rebecca L Openshaw, David M Thomson, Greg C Bristow, Emma J Mitchell, Judith A Pratt, Brian J Morris, Neil Dawso. 16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability. Communications biology. vol 6. issue 1. 2023-05-24. PMID:37225770. |
the data implicate cortical and septal gabaergic dysfunction, and resulting connectivity changes, as the cause of pre-attentional and attentional changes in autism. |
2023-05-24 |
2023-08-14 |
mouse |
| Brett D Dufour, Erin McBride, Trevor Bartley, Pablo Juarez, Verónica Martínez-Cerdeñ. Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors. Autism : the international journal of research and practice. 2023-03-20. PMID:36935610. |
distinct patterns of gabaergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors. |
2023-03-20 |
2023-08-14 |
Not clear |
| Yi Wang, Chunxue Liu, Jingxin Deng, Qiong Xu, Jia Lin, Huiping Li, Meixin Hu, Chunchun Hu, Qiang Li, Xiu X. Behavioral and Sensory Deficits Associated with Dysfunction of GABAergic System in a Novel International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768529. |
behavioral and sensory deficits associated with dysfunction of gabaergic system in a novel hyper-reactivity to sensory inputs is a common and debilitating symptom of autism spectrum disorder (asd), but the underlying neural abnormalities remain unclear. |
2023-02-11 |
2023-08-14 |
Not clear |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
the excitatory/inhibitory (e/i) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (gabaergic) mechanisms underlies the behavioral characteristics of autism. |
2023-01-21 |
2023-08-14 |
human |
| Mellanie Fontes-Dutra, Joseane Righes Marafiga, Júlio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Bruna Rabelo, Rafael Kazmierzak de Moraes, Marília Rockenbach, Mayara Vendramin Pasquetti, Carmem Gottfried, Maria Elisa Calcagnott. GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder. The European journal of neuroscience. 2022-12-12. PMID:36504470. |
gabaergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder. |
2022-12-12 |
2023-08-14 |
rat |