| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wisam Bazbaz, Maryam Kartawy, Wajeha Hamoudi, Shashank Kumar Ojha, Igor Khaliulin, Haitham Ama. The Role of Thioredoxin System in Shank3 Mouse Model of Autism. Journal of molecular neuroscience : MN. vol 74. issue 4. 2024-09-30. PMID:39347996. |
we hypothesize that the trx system is altered in the shank3 ko mouse model of autism, which may lead to a decreased activity of the nuclear factor erythroid 2-related factor 2 (nrf2), resulting in oxidative stress, and thus, contributing to asd-related phenotypes. |
2024-09-30 |
2024-10-02 |
mouse |
| Takahiro Tsuji, Kazumi Furuhara, Erchu Guo, Yijing Wu, Jing Zhong, Haruhiro Higashida, Yasuhiko Yamamoto, Chiharu Tsuj. Oral Supplementation of L-Carnosine Attenuates Acute-Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice. Nutrients. vol 16. issue 17. 2024-09-14. PMID:39275136. |
here, we assessed the effect of l-carnosine in cd157 knockout (ko) mice, a murine model of autism spectrum disorder (asd). |
2024-09-14 |
2024-09-16 |
mouse |
| Dilan Wellalage Don, Tae-Yoon Kim, Bin Na Hong, Jeong-Soo Lee, Tong Ho Kang, Robert Gerlai, Cheol-Hee Ki. A Simple Tube Escape Assay to Test Learning and Memory in Zebrafish with Minimized Habituation. Zebrafish. 2024-05-15. PMID:38748396. |
we also studied learning and memory of a gene knockout (ko) zebrafish that showed social impairments related to autism. |
2024-05-15 |
2024-05-27 |
zebrafish |
| Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, Akihiro Mouri, Norio Ozaki, Toshitaka Nabeshima, Kuniaki Sait. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2023-12-01. PMID:38037233. |
ido2 ko mice showed stereotyped behavior, restricted interest and social deficits, traits that are associated with behavioral endophenotypes of autism spectrum disorder (asd). |
2023-12-01 |
2023-12-10 |
mouse |
| Se Jin Jeon, Huiyoung Kwon, Ho Jung Bae, Edson Luck Gonzales, Junhyeong Kim, Hye Jin Chung, Dong Hyun Kim, Jong Hoon Ryu, Chan Young Shi. Agmatine relieves behavioral impairments in Fragile X mice model. Neuropharmacology. 2022-09-03. PMID:36057317. |
based on the recent successful demonstration of an endogenous polyamine, agmatine, to improve the autism-like symptoms in the valproic acid animal model of autism, we investigated the effects of agmatine against fxs symptoms using fmr1 knockout (ko) mice. |
2022-09-03 |
2023-08-14 |
mouse |
| Keegan Flanagan, Alireza Baradaran-Heravi, Qi Yin, Khanh Dao Duc, Allan C Spradling, Ethan J Greenblat. FMRP-dependent production of large dosage-sensitive proteins is highly conserved. Genetics. 2022-06-22. PMID:35731217. |
the steady state levels of several fmrp targets were reduced in the fmr1 ko mouse cortex, including a ∼2-fold reduction of auts2, a gene implicated in an autosomal dominant autism spectrum disorder. |
2022-06-22 |
2023-08-14 |
mouse |
| Ernest V Pedapati, Lauren M Schmitt, Lauren E Ethridge, Makoto Miyakoshi, John A Sweeney, Rui Liu, Elizabeth Smith, Rebecca C Shaffer, Kelli C Dominick, Donald L Gilbert, Steve W Wu, Paul S Horn, Devin K Binder, Martine Lamy, Megan Axford, Craig A Erickso. Neocortical localization and thalamocortical modulation of neuronal hyperexcitability contribute to Fragile X Syndrome. Communications biology. vol 5. issue 1. 2022-05-13. PMID:35546357. |
fragile x syndrome (fxs) is a monogenetic form of intellectual disability and autism in which well-established knockout (ko) animal models point to neuronal hyperexcitability and abnormal gamma-frequency physiology as a basis for key disorder features. |
2022-05-13 |
2023-08-13 |
Not clear |
| Marta Fernández, Carlos A Sánchez-León, Javier Llorente, Teresa Sierra-Arregui, Shira Knafo, Javier Márquez-Ruiz, Olga Peñagarikan. Altered Cerebellar Response to Somatosensory Stimuli in the eNeuro. vol 8. issue 5. 2021-12-10. PMID:34593517. |
we studied sensory processing in the cerebellum in a mouse model of autism, knock-out (ko) for the |
2021-12-10 |
2023-08-13 |
mouse |
| Gonzalo H Otazu, Yan Li, Zachary Lodato, Adel Elnasher, Katherine M Keever, Ying Li, Raddy L Ramo. Neurodevelopmental malformations of the cerebellum and neocortex in the Shank3 and Cntnap2 mouse models of autism. Neuroscience letters. vol 765. 2021-11-08. PMID:34555490. |
in the present report, we document the presence of cerebellar and neocortical heterotopia in heterozygous and ko shank3 and cntnap2 mice which are due to the c57bl/6 genotype and discuss the role these malformations may play in research using these genetic models of autism. |
2021-11-08 |
2023-08-13 |
mouse |
| Noriko Koganezawa, Kenji Hanamura, Manuela Schwark, Dilja Krueger-Burg, Hiroshi Kawab. Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice. Biochemical and biophysical research communications. vol 582. 2021-11-05. PMID:34715405. |
we discovered a region-specific increase in excitatory synapses in a model mouse of autism spectrum disorder, neuroligin-3 ko, with this method. |
2021-11-05 |
2023-08-13 |
mouse |
| Sehyoun Yoon, Nicolas H Piguel, Natalia Khalatyan, Leonardo E Dionisio, Jeffrey N Savas, Peter Penze. Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33398084. |
homer1 knockout (ko) mice show behavioral abnormalities related to psychiatric disorders, and homer1 has been associated with psychiatric disorders such as addiction, autism disorder (asd), schizophrenia (sz), and depression. |
2021-10-11 |
2023-08-13 |
mouse |
| Karo Talvio, Katja M Kanninen, Anthony R White, Jari Koistinaho, Maija L Castré. Increased iron content in the heart of the Fmr1 knockout mouse. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 34. issue 4. 2021-10-11. PMID:34089433. |
we assessed the concentrations of 23 trace minerals in different tissues (brain, spleen, heart and liver) of fmr1 knockout (ko) mice that display the main phenotype of fragile x syndrome (fxs), an intellectual disability syndrome and the best-known monogenic model of autism spectrum disorder (asd). |
2021-10-11 |
2023-08-13 |
mouse |
| Matthew S Binder, Dalton G Jones, Samantha L Hodges, Joaquin N Lug. NS-Pten adult knockout mice display both quantitative and qualitative changes in urine-induced ultrasonic vocalizations. Behavioural brain research. vol 378. 2021-04-28. PMID:31586563. |
the ns-pten knockout (ko) mouse exhibits hyperactivity of the mammalian target of rapamycin (mtor) and is a model of autism spectrum disorder (asd). |
2021-04-28 |
2023-08-13 |
mouse |
| Rebeca Mejias, Shu-Ling Chiu, Mei Han, Rebecca Rose, Ana Gil-Infante, Yifan Zhao, Richard L Huganir, Tao Wan. Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiology of disease. vol 132. 2020-08-06. PMID:31476380. |
to evaluate role of pc-ampar signaling in autism, we produced pc-specific grip1/2 knockout mice by crossing grip2 conventional and grip1 conditional ko with l7-cre driver mice. |
2020-08-06 |
2023-08-13 |
mouse |
| Jisoo Lim, Jiin Ryu, Shinwon Kang, Hyun Jong Noh, Chul Hoon Ki. Autism-like behaviors in male mice with a Pcdh19 deletion. Molecular brain. vol 12. issue 1. 2020-06-08. PMID:31747920. |
consistent with the autism observed in efmr females, we found pcdh19 heterozygous ko female mice (with mosaic expression of pcdh19) show defects in sociability in the 3-chamber test. |
2020-06-08 |
2023-08-13 |
mouse |
| Timothy D Folsom, LeeAnn Higgins, Todd W Markowski, Timothy J Griffin, S Hossein Fatem. Quantitative proteomics of forebrain subcellular fractions in fragile X mental retardation 1 knockout mice following acute treatment with 2-Methyl-6-(phenylethynyl)pyridine: Relevance to developmental study of schizophrenia. Synapse (New York, N.Y.). vol 73. issue 1. 2020-04-22. PMID:30176067. |
the fragile x mental retardation 1 knockout (fmr1 ko) mouse replicates behavioral deficits associated with autism, fragile x syndrome, and schizophrenia. |
2020-04-22 |
2023-08-13 |
mouse |
| Erratum: Soda et al., "Hyperexcitability and Hyperplasticity Disrupt Cerebellar Signal Transfer in the IB2 KO Mouse Model of Autism". The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 35. 2020-03-11. PMID:31444244. |
erratum: soda et al., "hyperexcitability and hyperplasticity disrupt cerebellar signal transfer in the ib2 ko mouse model of autism". |
2020-03-11 |
2023-08-13 |
mouse |
| Fabian Dorninger, Theresa König, Petra Scholze, Michael L Berger, Gerhard Zeitler, Christoph Wiesinger, Anna Gundacker, Daniela D Pollak, Sigismund Huck, Wilhelm W Just, Sonja Forss-Petter, Christian Pifl, Johannes Berge. Disturbed neurotransmitter homeostasis in ether lipid deficiency. Human molecular genetics. vol 28. issue 12. 2020-02-06. PMID:30759250. |
these features likely contribute to the behavioral phenotype of gnpat ko mice, potentially modeling some human neurodevelopmental disorders like autism or attention deficit hyperactivity disorder. |
2020-02-06 |
2023-08-13 |
mouse |
| Zhu Li, Rekha Jagadapillai, Evelyne Gozal, Gregory Barne. Deletion of Semaphorin 3F in Interneurons Is Associated with Decreased GABAergic Neurons, Autism-like Behavior, and Increased Oxidative Stress Cascades. Molecular neurobiology. vol 56. issue 8. 2019-12-12. PMID:30635860. |
further studies of mouse ko models of asd genes such as sema 3f or nrp2 may be informative to clinical phenotypes contributing to the pathogenesis in autism and epilepsy patients. |
2019-12-12 |
2023-08-13 |
mouse |
| Noa Sadigurschi, Hava M Gola. Maternal and offspring methylenetetrahydrofolate-reductase genotypes interact in a mouse model to induce autism spectrum disorder-like behavior. Genes, brain, and behavior. vol 18. issue 1. 2019-03-21. PMID:30552741. |
here, we report on the mthfr heterozygous knockout (ko) mouse as a rodent model of autism that shows the contributions of maternal and offspring genotypes to the development of autistic-like behaviors. |
2019-03-21 |
2023-08-13 |
mouse |