| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Li. Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism. Journal of neuroinflammation. vol 21. issue 1. 2024-10-19. PMID:39425203. |
transient csf1r inhibition ameliorates behavioral deficits in cntnap2 knockout and valproic acid-exposed mouse models of autism. |
2024-10-19 |
2024-10-21 |
mouse |
| Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Li. Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism. Journal of neuroinflammation. vol 21. issue 1. 2024-10-19. PMID:39425203. |
here, we report pharmacological functions and cellular mechanisms of plx5622, a small-molecule csf1r inhibitor, in treating cntnap2 knockout and valproic acid (vpa)-exposed autism model mice. |
2024-10-19 |
2024-10-21 |
mouse |
| Han Chin Wang, Daniel E Feldma. Degraded tactile coding in the Cntnap2 mouse model of autism. Cell reports. vol 43. issue 8. 2024-08-07. PMID:39110592. |
degraded tactile coding in the cntnap2 mouse model of autism. |
2024-08-07 |
2024-08-10 |
mouse |
| Vardan Arutiunian, Megha Santhosh, Emily Neuhaus, Catherine A W Sullivan, Raphael A Bernier, Susan Y Bookheimer, Mirella Dapretto, Daniel H Geschwind, Allison Jack, James C McPartland, John D Van Horn, Kevin A Pelphrey, Abha R Gupta, Sara Jane Web. A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. 2024-07-10. PMID:38984666. |
a common genetic variant in the neurexin family member cntnap2 is related to language but not communication skills in youth with autism spectrum disorder. |
2024-07-10 |
2024-07-12 |
human |
| Vardan Arutiunian, Megha Santhosh, Emily Neuhaus, Catherine A W Sullivan, Raphael A Bernier, Susan Y Bookheimer, Mirella Dapretto, Daniel H Geschwind, Allison Jack, James C McPartland, John D Van Horn, Kevin A Pelphrey, Abha R Gupta, Sara Jane Web. A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. 2024-07-10. PMID:38984666. |
one of the candidate genes related to language variability in individuals with autism spectrum disorder (asd) is the contactin-associated protein-like 2 gene (cntnap2), a member of the neurexin family. |
2024-07-10 |
2024-07-12 |
human |
| Qing Zhang, Mengen Xing, Zhengkai Bao, Lu Xu, Yang Bai, Wanqi Chen, Wenhao Pan, Fang Cai, Qunxian Wang, Shipeng Guo, Jing Zhang, Zhe Wang, Yili Wu, Yun Zhang, Jia-Da Li, Weihong Son. Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes. Signal transduction and targeted therapy. vol 9. issue 1. 2024-02-29. PMID:38424048. |
mutations in the contactin-associated protein-like 2 (cntnap2) gene are associated with autism spectrum disorder (asd), and ectodomain shedding of the cntnap2 protein plays a role in its function. |
2024-02-29 |
2024-03-03 |
Not clear |
| Qian Li, Wenbo Li, Kaiyue Hu, Yaqian Wang, Yang Li, Jiawei X. A de novo variant in RERE causes autistic behavior by disrupting related genes and signaling pathway. Clinical genetics. 2023-11-29. PMID:38018232. |
genes implicated in autism, such as cntnap2, stx1a, farp2, and gpc1, were significantly downregulated. |
2023-11-29 |
2023-12-07 |
Not clear |
| Han Chin Wang, Daniel E Feldma. Degraded tactile coding in the Cntnap2 mouse model of autism. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808857. |
degraded tactile coding in the cntnap2 mouse model of autism. |
2023-10-09 |
2023-10-15 |
mouse |
| Alessandra G Ciancone-Chama, Valerio Bonaldo, Emiliano Biasini, Yuri Bozzi, Luigi Balasc. Gene expression profiling in trigeminal ganglia from Cntnap2 Neuroscience. 2023-09-12. PMID:37699442. |
here we investigated the gene expression deregulation in the trigeminal ganglion (which directly receives tactile information from whiskers) in two genetic models of syndromic autism (shank3b and cntnap2 mutant mice) at both adult and juvenile ages. |
2023-09-12 |
2023-10-07 |
mouse |
| Tanya Gandhi, Cade R Canepa, Tolulope T Adeyelu, Philip A Adeniyi, Charles C Le. Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371370. |
neuroanatomical alterations in the cntnap2 mouse model of autism spectrum disorder. |
2023-06-28 |
2023-08-14 |
mouse |
| Tanya Gandhi, Chin-Chi Liu, Tolulope T Adeyelu, Cade R Canepa, Charles C Le. Behavioral regulation by perineuronal nets in the prefrontal cortex of the CNTNAP2 mouse model of autism spectrum disorder. Frontiers in behavioral neuroscience. vol 17. 2023-03-31. PMID:36998537. |
behavioral regulation by perineuronal nets in the prefrontal cortex of the cntnap2 mouse model of autism spectrum disorder. |
2023-03-31 |
2023-08-14 |
mouse |
| Frances St George-Hyslop, Moritz Haneklaus, Toomas Kivisild, Frederick J Livese. Loss of CNTNAP2 alters human cortical excitatory neuron differentiation and neural network development. Biological psychiatry. 2023-03-31. PMID:37001843. |
loss-of-function mutations in the contactin-associated protein-like 2 (cntnap2) gene are causal for neurodevelopmental disorders, including autism, schizophrenia, epilepsy and intellectual disability. |
2023-03-31 |
2023-08-14 |
human |
| Rajkamalpreet S Mann, Brian L Allman, Susanne Schmi. Developmental changes in electrophysiological properties of auditory cortical neurons in the Cntnap2 knockout rat. Journal of neurophysiology. 2023-03-22. PMID:36947880. |
disruptions in the cntnap2 gene are known to cause language impairments and symptoms associated with autism spectrum disorder (asd). |
2023-03-22 |
2023-08-14 |
rat |
| Dorit Möhrle, Megan Yuen, Alice Zheng, Faraj L Haddad, Brian L Allman, Susanne Schmi. Characterizing maternal isolation-induced ultrasonic vocalizations in a gene-environment interaction rat model for autism. Genes, brain, and behavior. 2023-02-08. PMID:36751016. |
of the many risk factors for autism spectrum disorder, the contactin-associated protein-like 2 gene, cntnap2, is thought to be important for language development. |
2023-02-08 |
2023-08-14 |
rat |
| Alice Zheng, Kaela E Scott, Ashley L Schormans, Rajkamalpreet Mann, Brian L Allman, Susanne Schmi. Differences in startle and prepulse inhibition in Cntnap2 knock-out rats are associated with sex-specific alterations in brainstem neural activity. Neuroscience. 2023-01-28. PMID:36708798. |
mutations in cntnap2 are associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. |
2023-01-28 |
2023-08-14 |
rat |
| Qing Zhang, Keenan Sterling, Lu Xu, Mengen Xing, Fang Cai, Sheng Yu, Isabel Bestard-Lorigados, Weihong Son. CNTNAP2 Protein Is Degraded by the Ubiquitin-Proteasome System and the Macroautophagy-Lysosome Pathway. Molecular neurobiology. 2023-01-19. PMID:36658382. |
cntnap2 has been widely investigated as a risk gene for autism spectrum disorder (asd), and recent studies also implicated cntnap2 in alzheimer's disease (ad). |
2023-01-19 |
2023-08-14 |
human |
| Yuka Shiota, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Sumie Iwasaki, Masuhiko Sano, Kyung-Min An, Shigeru Yokoyama, Mitsuru Kikuch. Effect of CNTNAP2 polymorphism on receptive language in children with autism Spectrum disorder without language developmental delay. Neuropsychopharmacology reports. 2022-06-23. PMID:35733350. |
effect of cntnap2 polymorphism on receptive language in children with autism spectrum disorder without language developmental delay. |
2022-06-23 |
2023-08-14 |
Not clear |
| Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Francesca Viscido, Alessandra Georgette Ciancone Chama, Alberto Galbusera, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozz. Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2 Neurobiology of disease. 2022-04-28. PMID:35483565. |
loss-of-function mutations in cntnap2 result in cortical dysplasia-focal epilepsy syndrome (cdfe) and autism. |
2022-04-28 |
2023-08-13 |
mouse |
| Kaela E Scott, Rajkamalpreet S Mann, Ashley L Schormans, Susanne Schmid, Brian L Allma. Hyperexcitable and Immature-Like Neuronal Activity in the Auditory Cortex of Adult Rats Lacking the Language-Linked CNTNAP2 Gene. Cerebral cortex (New York, N.Y. : 1991). 2022-02-02. PMID:35106542. |
the contactin-associated protein-like 2 gene, cntnap2, is a highly penetrant risk gene thought to play a role in the genetic etiology of language-related disorders, such as autism spectrum disorder and developmental language disorder. |
2022-02-02 |
2023-08-13 |
human |
| M Dolores Martín-de-Saavedra, Marc Dos Santos, Lorenza Culotta, Olga Varea, Benjamin P Spielman, Euan Parnell, Marc P Forrest, Ruoqi Gao, Sehyoun Yoon, Emmarose McCoig, Hiba A Jalloul, Kristoffer Myczek, Natalia Khalatyan, Elizabeth A Hall, Liam S Turk, Antonio Sanz-Clemente, Davide Comoletti, Stefan F Lichtenthaler, Jeffrey S Burgdorf, Maria V Barbolina, Jeffrey N Savas, Peter Penze. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca Neuron. 2021-12-18. PMID:34921780. |
cntnap2 undergoes activity-dependent es via mmp9 (matrix metalloprotease 9), and cntnap2-ecto levels are reduced in the hcsf of individuals with autism spectrum disorder. |
2021-12-18 |
2023-08-13 |
human |