| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong-In Park, Seung-Youn Jung, Kyung-Hee Song, Dong-Hyeon Lee, Jiyeon Ahn, Sang-Gu Hwang, In-Su Jung, Dae-Seog Lim, Jie-Young Son. Predictive DNA damage signaling for low‑dose ionizing radiation. International journal of molecular medicine. vol 53. issue 6. 2024-05-02. PMID:38695243. |
notably, the activation of ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2), p53 and h2a histone family member x (h2ax) significantly increased in a concentration‑dependent manner, which was also observed in human peripheral blood mononuclear cells. |
2024-05-02 |
2024-05-04 |
human |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Atar Singh Kushwah, Shireen Masood, Rajnikant Mishra, Monisha Banerje. Genetic and epigenetic alterations in DNA repair genes and treatment outcome of Chemoradiotherapy in Cervical cancer. Critical reviews in oncology/hematology. 2023-12-20. PMID:38122918. |
hpv oncoproteins e6 and e7 target p53 and rb (retinoblastoma) protein degradation, ataxia telangiectasia mutated (atm), atm-rad3-related (atr) inactivation and subsequent impairment of non-homologous end joining (nhej), homologous recombination, and base excision repair pathways. |
2023-12-20 |
2023-12-23 |
human |
| Byung Chul Jung, Sung Hoon Kim, Yoonjung Cho, Yoon Suk Ki. Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells. BMB reports. 2023-09-07. PMID:37679297. |
in addition, parkin caused dna damage and atm (ataxia telangiectasia mutated) activation, which subsequently led to p53 activation. |
2023-09-07 |
2023-10-07 |
human |
| Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidi. Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555751. |
the latter induced dna damage, ataxia telangiectasia mutated kinase (atm), and p53 phosphorylation. |
2022-12-23 |
2023-08-14 |
human |
| Ewud Agborbesong, Julie X Zhou, Linda X Li, Peter C Harris, James P Calvet, Xiaogang L. Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis. Human molecular genetics. 2022-09-06. PMID:36067023. |
we show that prdx5 regulates ddr through: 1) polo-like kinase 1 (plk1) mediated phosphorylation of ataxia telangiectasia mutated (atm) kinase to further trigger downstream mediators chek1 and chek2; 2) the increase of the acetylation of p53 at lysine 382, stabilizing p53 in the nucleus and enhancing transcription; 3) the induction of autophagy, which regulates the recycling of molecules involved in ddr. |
2022-09-06 |
2023-08-14 |
Not clear |
| Yong Jung Kang, Jung Yoon Jang, Young Hoon Kwon, Jun Ho Lee, Sanggwon Lee, Yujin Park, Young-Suk Jung, Eunok Im, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163511. |
treatment with mhy2245 decreased sirt1 activity and caused dna damage, leading to the upregulation of p53 acetylation, and increased levels of p53, phosphorylation of h2a histone family member x, ataxia telangiectasia and rad3-related kinase, checkpoint kinase 1 (chk1), and chk2. |
2022-02-15 |
2023-08-13 |
human |
| Craig K Docherty, Anastasiya Strembitska, Christa P Baker, Fiona F Schmidt, Kieran Reay, John R Merce. Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008643. |
analysis of human and murine plaques highlights markers of dna damage such as p53, ataxia telangiectasia mutated (atm), and defects in mitochondrial oxidative metabolism as significant observations. |
2022-01-11 |
2023-08-13 |
human |
| Sujeong Lee, Hyunyoung Yoon, Jiwoo Han, Kyung Lib Jan. Hepatitis C virus core protein inhibits hepatitis B virus replication by downregulating HBx levels via Siah-1-mediated proteasomal degradation during coinfection. The Journal of general virology. vol 102. issue 12. 2021-12-09. PMID:34882535. |
for this effect, hcv core protein increased reactive oxygen species levels in the mitochondria and activated the ataxia telangiectasia mutated-checkpoint kinase two pathway in the nucleus, resulting in an upregulation of p53 levels. |
2021-12-09 |
2023-08-13 |
human |
| Martijn R H Zwinderman, Thamar Jessurun Lobo, Petra E van der Wouden, Diana C J Spierings, Marcel A T M van Vugt, Peter M Lansdorp, Victor Guryev, Frank J Dekke. Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions. ACS chemical biology. vol 16. issue 11. 2021-11-25. PMID:34592816. |
strikingly, replication stress induced by hydroxyurea or curaxin treatment and inhibition of ataxia telangiectasia and rad3-related protein (atr) or p53 inactivation inverted the observed chromatin protein deposition bias to the strand replicated by the leading strand polymerase in line with previously reported effects on replication protein a occupancy. |
2021-11-25 |
2023-08-13 |
Not clear |
| Pengyi Yan, Zixuan Li, Junhao Xiong, Zilong Geng, Weiting Wei, Yan Zhang, Gengze Wu, Tao Zhuang, Xiaoyu Tian, Zhijie Liu, Junling Liu, Kun Sun, Fengyuan Chen, Yuzhen Zhang, Chunyu Zeng, Yu Huang, Bing Zhan. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell reports. vol 37. issue 8. 2021-11-24. PMID:34818543. |
dna damage-mediated ataxia telangiectasia mutated (atm) activation triggers the extracellular shuttling and downregulation of larp7, which dampens sirt1 deacetylase activity, enhances p53 and nf-κb (p65) transcriptional activity by augmenting their acetylation, and thereby accelerates cellular senescence. |
2021-11-24 |
2023-08-13 |
Not clear |
| Radka Storchova, Kamila Burdova, Matous Palek, René H Medema, Libor Macure. A novel assay for screening WIP1 phosphatase substrates in nuclear extracts. The FEBS journal. vol 288. issue 20. 2021-11-12. PMID:33982878. |
ddr is triggered by activation of ataxia telangiectasia mutated/ataxia telangiectasia and rad3-related protein kinases that phosphorylate multiple targets including tumor suppressor protein tumor suppressor p53 (p53). |
2021-11-12 |
2023-08-13 |
Not clear |
| Yuichi Nishiyama, Akinori Morita, Shogo Tatsuta, Misaki Kanamaru, Masahiro Sakaue, Kenta Ueda, Manami Shono, Rie Fujita, Bing Wang, Yoshio Hosoi, Shin Aoki, Takeshi Suga. Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome. Genes. vol 12. issue 10. 2021-10-26. PMID:34680909. |
although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (atm) and enhanced 53bp1 recruitment in irradiated cells. |
2021-10-26 |
2023-08-13 |
mouse |
| Narasimharao Nalabothula, Devulapalli Chakravarty, Adam Pierce, France Carrie. Over Expression of Nucleophosmin and Nucleolin Contributes to the Suboptimal Activation of a G2/M Checkpoint in Ataxia Telangiectasia Fibroblasts. Molecular and cellular pharmacology. vol 2. issue 5. 2021-10-20. PMID:21499441. |
ataxia telangiectasia (at) cells exhibit suboptimal activation of radiation-induced cell cycle checkpoints despite having a wild type p53 genotype. |
2021-10-20 |
2023-08-12 |
Not clear |
| Ryan L Hanson, Eric Batchelo. Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest. Cell reports. vol 33. issue 2. 2021-09-21. PMID:33053351. |
dna double strand breaks induce oscillatory expression of the transcription factor p53 that is dependent on ataxia telangiectasia mutated (atm) activity and the rate of double strand break resolution. |
2021-09-21 |
2023-08-13 |
Not clear |
| Sona Hubackova, Eliska Davidova, Stepana Boukalova, Jaromira Kovarova, Martina Bajzikova, Ana Coelho, Mikkel G Terp, Henrik J Ditzel, Jakub Rohlena, Jiri Neuzi. Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors. Cell death & disease. vol 11. issue 2. 2021-03-09. PMID:32034120. |
mechanistically, a block in replication and ribosomal biogenesis result in p53 activation paralleled by accumulation of replication forks that activate the ataxia telangiectasia and rad3-related kinase/chk1 pathway, both of which lead to cell cycle arrest. |
2021-03-09 |
2023-08-13 |
Not clear |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
key proteins of the dna damage response (ddr), including tumor protein p53 (p53, also known as tp53 or trp53 in rodents) and ataxia telangiectasia mutated (atm), a kinase known to act upstream of p53, have been associated with t2d. |
2020-10-20 |
2023-08-13 |
rat |
| Zhenyu Hou, Yunfeng Cui, Huizhi Xing, Xiaoyan M. Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434894. |
subsequently, ataxia telangiectasia mutated (atm) activity was inhibited alongside down-expression of parp-1 resulting in significantly decreased cellular viability of panc-1 cells, increased p53 protein expression, decreased expression of pro-caspase-3, increased caspase-3 activity and suppressed bcl-2 protein expression, when compared with parp-1 suppression alone. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhi-Peng Wang, Ye Tian, Jun Li. Role of wild-type p53-induced phosphatase 1 in cancer. Oncology letters. vol 14. issue 4. 2020-09-30. PMID:28959360. |
it has been reported to dephosphorylate p53, ataxia telangiectasia mutated, checkpoint kinase 1 and p38 mitogen activated protein kinases, forming negative feedback loops to inhibit apoptosis and cell cycle arrest. |
2020-09-30 |
2023-08-13 |
human |
| Cinzia Fionda, Danilo Di Bona, Andrea Kosta, Helena Stabile, Angela Santoni, Marco Cippitell. The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress. Cancers. vol 11. issue 6. 2020-09-29. PMID:31212703. |
the induction of oct-6 occurs at the transcriptional level via reactive oxygen species (ros) and ataxia telangiectasia mutated- and rad3-related (atr)-dependent mechanisms, but in a p53 independent manner. |
2020-09-29 |
2023-08-13 |
Not clear |