| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong-In Park, Seung-Youn Jung, Kyung-Hee Song, Dong-Hyeon Lee, Jiyeon Ahn, Sang-Gu Hwang, In-Su Jung, Dae-Seog Lim, Jie-Young Son. Predictive DNA damage signaling for low‑dose ionizing radiation. International journal of molecular medicine. vol 53. issue 6. 2024-05-02. PMID:38695243. |
notably, the activation of ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2), p53 and h2a histone family member x (h2ax) significantly increased in a concentration‑dependent manner, which was also observed in human peripheral blood mononuclear cells. |
2024-05-02 |
2024-05-04 |
human |
| Kang Ning, Xiujuan Zhang, Zehua Feng, Siyuan Hao, Cagla Aksu Kuz, Fang Cheng, Soo Yuen Park, Shane McFarlin, John F Engelhardt, Ziying Yan, Jianming Qi. Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium. Molecular therapy. Methods & clinical development. vol 31. 2023-10-16. PMID:37841417. |
this study found that recombinant aav2.5t (raav2.5t) transduction of well-differentiated primary human airway epithelia induced a dna damage response (ddr) characterized by the phosphorylation of replication protein a32 (rpa32), histone variant h2ax (h2a histone family member x), and all three phosphatidylinositol 3-kinase-related kinases: ataxia telangiectasia mutated kinase, ataxia telangiectasia and rad3-related kinase (atr), and dna-dependent protein kinase catalytic subunit (dna-pk |
2023-10-16 |
2023-11-08 |
human |
| Watanya Trakarnphornsombat, Hiroshi Kimur. Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate Response to DNA Damage. Journal of cell science. 2023-03-31. PMID:36999484. |
on the induction of dsbs, histone h2ax becomes phosphorylated by kinases, including ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), and dna-dependent protein kinase (dna-pk). |
2023-03-31 |
2023-08-14 |
Not clear |
| Jennifer Q J Zhang, Sayanthooran Saravanabavan, Ashley N Chandra, Alexandra Munt, Annette T Y Wong, Peter C Harris, David C H Harris, Paul McKenzie, Yiping Wang, Gopala K Ranga. Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease. The American journal of pathology. vol 191. issue 5. 2021-05-17. PMID:33549515. |
in end-stage human adpkd tissue, γ-h2a histone family member x (h2ax), phosphorylated ataxia telangiectasia and radiation-sensitive mutant 3 (rad3)-related (patr), and phosphorylated ataxia telangiectasia mutated (patm) localized to cystic kidney epithelial cells. |
2021-05-17 |
2023-08-13 |
human |
| Carole Beck, Sergio Castañeda-Zegarra, Camilla Huse, Mengtan Xing, Valentyn Oksenyc. Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF. Biomolecules. vol 10. issue 1. 2020-09-22. PMID:31905950. |
dna double-strand breaks (dsbs) trigger the ataxia telangiectasia mutated (atm)-dependent dna damage response (ddr), which consists of histone h2ax, mdc1, rnf168, 53bp1, ptip, rif1, rev7, and shieldin. |
2020-09-22 |
2023-08-13 |
mouse |
| Mei-Jen Wang, Hsin-Yi Huang, Tsung-Lang Chiu, Hui-Fen Chang, Hsin-Rong W. Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis. Cells. vol 9. issue 1. 2020-08-24. PMID:31861721. |
additionally, downregulation of prx5 augmented rotenone-induced dna damage manifested as induction of phosphorylated histone h2ax (γ-h2ax) and activation of ataxia telangiectasia mutated (atm) kinase. |
2020-08-24 |
2023-08-13 |
rat |
| Jessica M Stringer, Amy Winship, Nadeen Zerafa, Matthew Wakefield, Karla Hut. Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 21. 2020-08-18. PMID:32381741. |
here we show that prophase-arrested oocytes rapidly respond to γ-irradiation-induced dna double-strand breaks by activating ataxia telangiectasia mutated, phosphorylating histone h2ax, and localizing rad51 to the sites of dna damage. |
2020-08-18 |
2023-08-13 |
Not clear |
| Julie H Wu, Deepika Narayanan, Allison L Limmer, Rebecca A Simonette, Peter L Rady, Stephen K Tyrin. Merkel Cell Polyomavirus Small T Antigen Induces DNA Damage Response. Intervirology. vol 62. issue 2. 2019-12-13. PMID:31401636. |
we observed that overexpression of mcpyv st antigen induced the phosphorylation of histone h2ax as well as the activation of ataxia telangiectasia mutant (atm), an upstream kinase important for h2ax phosphorylation. |
2019-12-13 |
2023-08-13 |
human |
| Jiangsong Jiang, Nishant Mohan, Yukinori Endo, Yi Shen, Wen Jin W. Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity. Oncotarget. vol 9. issue 5. 2019-11-20. PMID:29464058. |
this in turn induces dna damage activity and dna double strand breaks, which is indicated by the enhanced phosphorylation of h2ax (γh2ax) and ataxia telangiectasia and rad3-related protein (atr ps428) in trastuzumab-treated cardiomyocytes. |
2019-11-20 |
2023-08-13 |
human |
| Jie Yang, Fan Yu, Jinlei Guan, Tao Wang, Changjiang Liu, Yuxiang Wang, Guangjie Liu, Shuchai Zh. Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 97. issue 5. 2019-11-14. PMID:30673298. |
interaction among ataxia telangiectasia mutated protein (atm), mediator of dna damage checkpoint 1 (mdc1), and h2ax were examined. |
2019-11-14 |
2023-08-13 |
Not clear |
| Hong Zhao, H Dorota Halicka, Jorge Garcia, Jiangwei Li, Zbigniew Darzynkiewic. ATM Activation and H2AX Phosphorylation Induced by Genotoxic Agents Assessed by Flow- and Laser Scanning Cytometry. Methods in molecular biology (Clifton, N.J.). vol 1599. 2018-02-20. PMID:28477120. |
activation of ataxia telangiectasia mediated protein kinase (atm) by its phosphorylation on serine 1981 and phosphorylation of histone h2ax on serine 139 (γh2ax) are the key events reporting dna damage, primarily formation of dna double strand breaks. |
2018-02-20 |
2023-08-13 |
Not clear |
| Kellen Cristine Tjioe, Denise Tostes Oliveira, Julie Gavar. Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma. Nutrition and cancer. vol 68. issue 5. 2018-01-02. PMID:27266882. |
from a molecular standpoint, luteolin causes phosphorylation of ataxia telangiectasia mutated (atm) and h2ax in a dna repair pathway and can be efficiently combined with a checkpoint kinase (chk) pharmacological inhibitor. |
2018-01-02 |
2023-08-13 |
Not clear |
| Shan Xu, Yu Ying Tang, Yan Xin Yu, Qin Yun, Jing Pin Yang, Heng Zhang, Qiuxia Peng, Xiaoyang Sun, Ling Lin Yang, ShaoZhi Fu, Jing Bo W. Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma. Drug delivery. vol 24. issue 1. 2017-12-14. PMID:28797171. |
pdmp + radiotherapy treatment was most effective in inhibiting tumor growth, prolonging survival time, decreasing expression of cd31, cd133, and aldehyde dehydrogenase 1 (aldh1), inducing g2/m phase arrest, apoptosis, and expression of ataxia telangiectasia mutated (atm) and histone h2ax phosphorylation (γ-h2ax). |
2017-12-14 |
2023-08-13 |
mouse |
| Yi-Li Feng, Ji-Feng Xiang, Si-Cheng Liu, Tao Guo, Guo-Fang Yan, Ye Feng, Na Kong, Hao-Dan Li, Yang Huang, Hui Lin, Xiu-Jun Cai, An-Yong Xi. H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic acids research. vol 45. issue 18. 2017-11-07. PMID:28977657. |
epistasis analysis revealed that ataxia telangiectasia mutated (atm) and the chromatin remodeling complex tip60/trrap/p400 are essential for this h2ax function. |
2017-11-07 |
2023-08-13 |
Not clear |
| Prashant Rai, Fang He, Jimmy Kwang, Bevin P Engelward, Vincent T K Cho. Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest. Scientific reports. vol 6. 2017-01-30. PMID:27026501. |
here, we show that pneumolysin, which is released during bacterial lysis, induces dna double strand breaks (dsbs), as indicated by ataxia telangiectasia mutated (atm)-mediated h2ax phosphorylation (γh2ax). |
2017-01-30 |
2023-08-13 |
Not clear |
| Akshay K Ahuja, Karolina Jodkowska, Federico Teloni, Anna H Bizard, Ralph Zellweger, Raquel Herrador, Sagrario Ortega, Ian D Hickson, Matthias Altmeyer, Juan Mendez, Massimo Lope. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nature communications. vol 7. 2016-06-28. PMID:26876348. |
here we show in cultured escs and mouse embryos that h2ax phosphorylation is dependent on ataxia telangiectasia and rad3 related (atr) and is associated with chromatin loading of the ssdna-binding proteins rpa and rad51. |
2016-06-28 |
2023-08-13 |
mouse |
| Indrabahadur Singh, Nihan Ozturk, Julio Cordero, Aditi Mehta, Diya Hasan, Claudia Cosentino, Carlos Sebastian, Marcus Krüger, Mario Looso, Gianni Carraro, Saverio Bellusci, Werner Seeger, Thomas Braun, Raul Mostoslavsky, Guillermo Barret. High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell research. vol 25. issue 7. 2016-06-01. PMID:26045162. |
we combined proteomic, chip-seq, and transcriptome data to show that hmga2-induced transcription requires phosphorylation of the histone variant h2ax at s139 (h2axs139ph; γ-h2ax) mediated by the protein kinase ataxia telangiectasia mutated (atm). |
2016-06-01 |
2023-08-13 |
Not clear |
| Yih-Wen Chen, Robert A Harris, Zafer Hatahet, Kai-ming Cho. Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 33. 2016-04-29. PMID:26240351. |
in comparison to wt mice, adipose tissue from pol η(-/-) mice exhibits increased dna damage and a greater dna damage response, indicated by up-regulation and/or phosphorylation of ataxia telangiectasia mutated (atm), phosphorylated h2ax (γh2ax), and poly[adp-ribose] polymerase 1 (parp-1). |
2016-04-29 |
2023-08-13 |
mouse |
| Laureen C Colis, Denise C Hegan, Miho Kaneko, Peter M Glazer, Seth B Herzo. Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. Journal of the American Chemical Society. vol 137. issue 17. 2016-03-14. PMID:25849366. |
both 1 and 3 induce ataxia telangiectasia mutated- (atm-) and dna-dependent protein kinase- (dna-pk-) dependent production of phospho-ser139-histone h2ax (γh2ax) and generation of p53 binding protein 1 (53bp1) foci in k562 cells within 1 h of exposure, which is indicative of activation of nonhomologous end joining (nhej) and homologous recombination (hr) repair. |
2016-03-14 |
2023-08-13 |
human |
| Prashant Rai, Marcus Parrish, Ian Jun Jie Tay, Na Li, Shelley Ackerman, Fang He, Jimmy Kwang, Vincent T Chow, Bevin P Engelwar. Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 26. 2015-11-17. PMID:26080406. |
here, we show that s. pneumoniae induces toxic dna double-strand breaks (dsbs) in human alveolar epithelial cells, as indicated by ataxia telangiectasia mutated kinase (atm)-dependent phosphorylation of histone h2ax and colocalization with p53-binding protein (53bp1). |
2015-11-17 |
2023-08-13 |
human |