| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jialin Li, Anita Haj Ebrahimi, Afia B Al. Advances in Therapeutics to Alleviate Cognitive Decline and Neuropsychiatric Symptoms of Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791206. |
the first-line treatment options for the management of nps are selective serotonin reuptake inhibitors/selective noradrenaline reuptake inhibitors (ssris/snris) targeting the monoaminergic system; however, they are not rational drug choices for the management of anxiety disorders since the gabaergic system has a prominent role in their development. |
2024-05-25 |
2024-05-27 |
Not clear |
| Pamela Biernacki, Karan Kvern. Treatment of Anxiety Disorders in Primary Care: What Nurse Practitioners Need to Know. Journal of psychosocial nursing and mental health services. vol 62. issue 5. 2024-05-06. PMID:38709090. |
confronting primary care nps are problems with time constraints, multiple comorbidities, and limited mental health training, particularly in relation to the differences in pharmacokinetic and pharmacodynamic actions of first-line anxiety disorder medications across age groups. |
2024-05-06 |
2024-05-08 |
Not clear |
| Hayriye Baykan, Özgür Baykan, Onur Durmaz, Hayrettin Kara, Adnan Adil Hişmioğullari, Tunay Karlider. Plasma Neuropeptide-S Levels in Populations Diagnosed with Generalized Anxiety Disorder: A Controlled Study. Noro psikiyatri arsivi. vol 56. issue 1. 2020-10-01. PMID:30911238. |
the aim of this study was to compare the plasma nps levels in patients suffering from generalized anxiety disorder (gad) and those of healthy controls. |
2020-10-01 |
2023-08-13 |
Not clear |
| Malgorzata H Kolodziejczyk, Markus Fend. Corticosterone Treatment and Incubation Time After Contextual Fear Conditioning Synergistically Induce Fear Memory Generalization in Neuropeptide S Receptor-Deficient Mice. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32231512. |
the neuropeptide s (nps) receptor (npsr) has been shown to be associated with anxiety disorders and has recently been identified as a promising target for treating anxiety disorders. |
2020-09-28 |
2023-08-13 |
mouse |
| Thomas Grund, Inga D Neuman. Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell and tissue research. vol 375. issue 1. 2019-04-08. PMID:30112573. |
therefore, nps might represent a treatment option for neuropsychiatric disorders, such as anxiety disorders, even more so as single nucleotide polymorphisms in the human nps receptor gene have been associated with increased anxiety traits that contribute to the pathogenesis of fear- and anxiety-related disorders. |
2019-04-08 |
2023-08-13 |
human |
| Qianqian He, Zhongxia Shen, Lie Ren, Xing Wang, Mincai Qian, Jianying Zhu, Xinhua She. Association of NPSR1 rs324981 polymorphism and treatment response to antidepressants in Chinese Han population with generalized anxiety disorder. Biochemical and biophysical research communications. vol 504. issue 1. 2019-03-25. PMID:30190127. |
in previous studies, neuropeptide s (nps) and its cognate receptor (npsr) have been involved in the pathogenesis of anxiety disorders in previous studies. |
2019-03-25 |
2023-08-13 |
human |
| Thomas Grund, Stephanie Goyon, Yuting Li, Marina Eliava, Haikun Liu, Alexandre Charlet, Valery Grinevich, Inga D Neuman. Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 50. 2018-01-19. PMID:29118105. |
neuropeptides, such as neuropeptide s (nps) and oxytocin (oxt), represent potential options for the treatment of anxiety disorders due to their potent anxiolytic profile. |
2018-01-19 |
2023-08-13 |
rat |
| Anne Guhn, Katharina Domschke, Laura D Müller, Thomas Dresler, Florian Eff, Juliane Kopf, Jürgen Deckert, Andreas Reif, Martin J Herrman. Neuropeptide S receptor gene variation and neural correlates of cognitive emotion regulation. Social cognitive and affective neuroscience. vol 10. issue 12. 2016-07-11. PMID:25971599. |
the neuropeptide s (nps) and its receptor npsr have captured attention in the pathogenesis of anxiety disorders. |
2016-07-11 |
2023-08-13 |
human |
| Julien Dine, Irina A Ionescu, Charilaos Avrabos, Yi-Chun Yen, Florian Holsboer, Rainer Landgraf, Ulrike Schmidt, Matthias Ede. Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one. PloS one. vol 10. issue 4. 2015-12-23. PMID:25830625. |
based on previous findings, we also examined whether intranasal delivery of neuropeptide s (nps), which increasingly emerges as a potential novel treatment option for anxiety symptoms occurring in a variety of diseases like anxiety disorders, posttraumatic stress disorder, and major depression, impacts on the high-anxiety electrophysiological endophenotype in hab mice. |
2015-12-23 |
2023-08-13 |
mouse |
| Sara V Tupak, Andreas Reif, Paul Pauli, Thomas Dresler, Martin J Herrmann, Katharina Domschke, Clara Jochum, Elisabeth Haas, Christian Baumann, Heike Weber, Andreas J Fallgatter, Jürgen Deckert, Ann-Christine Ehli. Neuropeptide S receptor gene: fear-specific modulations of prefrontal activation. NeuroImage. vol 66. 2015-08-06. PMID:23103692. |
since central administration of neuropeptide s (nps) has been shown to exert anxiolytic effects on rodent behavior in a number of studies, genetic variants of its cognate g-protein coupled receptor (npsr1) became the focus of several recent human studies on anxiety and anxiety disorders. |
2015-08-06 |
2023-08-12 |
human |
| Carla Hassler, Yanan Zhang, Brian Gilmour, Tyler Graf, Timothy Fennell, Rodney Snyder, Jeffrey R Deschamps, Rainer K Reinscheid, Celia Garau, Scott P Runyo. Identification of neuropeptide S antagonists: structure-activity relationship studies, X-ray crystallography, and in vivo evaluation. ACS chemical neuroscience. vol 5. issue 8. 2015-05-11. PMID:24964000. |
modulation of the neuropeptide s (nps) system has been linked to a variety of cns disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, ptsd, and substance abuse. |
2015-05-11 |
2023-08-13 |
mouse |
| Christian Beste, Carsten Konrad, Christina Uhlmann, Volker Arolt, Peter Zwanzger, Katharina Domschk. Neuropeptide S receptor (NPSR1) gene variation modulates response inhibition and error monitoring. NeuroImage. vol 71. 2013-08-23. PMID:23319044. |
these findings further corroborate a major role of the neuropeptide s system in the pathogenesis of anxiety and suggest a potentially beneficial use of therapeutic agents targeting the nps system in anxiety disorders. |
2013-08-23 |
2023-08-12 |
human |
| Evelyn Glotzbach-Schoon, Marta Andreatta, Andreas Reif, Heike Ewald, Christian Tröger, Christian Baumann, Jürgen Deckert, Andreas Mühlberger, Paul Paul. Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle. Frontiers in behavioral neuroscience. vol 7. 2013-05-01. PMID:23630477. |
the serotonin (5-ht) and neuropeptide s (nps) systems are discussed as important genetic modulators of fear and sustained anxiety contributing to the etiology of anxiety disorders. |
2013-05-01 |
2023-08-12 |
human |
| Udo Dannlowski, Harald Kugel, Friederike Franke, Anja Stuhrmann, Christa Hohoff, Peter Zwanzger, Thomas Lenzen, Dominik Grotegerd, Thomas Suslow, Volker Arolt, Walter Heindel, Katharina Domschk. Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 9. 2012-05-08. PMID:21525857. |
recent studies point to a role of neuropeptide-s (nps) in the etiology of anxiety disorders. |
2012-05-08 |
2023-08-12 |
human |
| Udo Dannlowski, Harald Kugel, Friederike Franke, Anja Stuhrmann, Christa Hohoff, Peter Zwanzger, Thomas Lenzen, Dominik Grotegerd, Thomas Suslow, Volker Arolt, Walter Heindel, Katharina Domschk. Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 9. 2012-05-08. PMID:21525857. |
in animal models, nps and its receptor (npsr) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive in anxiety disorders. |
2012-05-08 |
2023-08-12 |
human |
| Jonas Donner, Rita Haapakoski, Sini Ezer, Erik Melén, Sami Pirkola, Mònica Gratacòs, Marco Zucchelli, Francesca Anedda, Lovisa E Johansson, Cilla Söderhäll, Christina Orsmark-Pietras, Jaana Suvisaari, Rocío Martín-Santos, Marta Torrens, Kaisa Silander, Joseph D Terwilliger, Magnus Wickman, Göran Pershagen, Jouko Lönnqvist, Leena Peltonen, Xavier Estivill, Mauro D'Amato, Juha Kere, Harri Alenius, Iiris Hovatt. Assessment of the neuropeptide S system in anxiety disorders. Biological psychiatry. vol 68. issue 5. 2010-12-20. PMID:20705147. |
we addressed here the role of nps and npsr1 as susceptibility genes for human anxiety disorders. |
2010-12-20 |
2023-08-12 |
human |
| b' Giovanni Vitale, Monica Filaferro, Valentina Ruggieri, Sonia Pennella, Claudio Frigeri, Anna Rizzi, Remo Guerrini, Girolamo Cal\\xc3\\xb. Anxiolytic-like effect of neuropeptide S in the rat defensive burying. Peptides. vol 29. issue 12. 2009-02-19. PMID:18793688.' |
in conclusion, we provide further evidence that nps evokes genuine anxiolytic-like effects in the rat; therefore npsr selective agonists are worthy of development as innovative drugs for the treatment of anxiety disorders. |
2009-02-19 |
2023-08-12 |
human |
| Kay Jüngling, Thomas Seidenbecher, Ludmila Sosulina, Jörg Lesting, Susan Sangha, Stewart D Clark, Naoe Okamura, Dee M Duangdao, Yan-Ling Xu, Rainer K Reinscheid, Hans-Christian Pap. Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron. vol 59. issue 2. 2008-08-26. PMID:18667157. |
these results identify mechanisms of nps in the brain, a key role of intercalated neurons in the amygdala for fear extinction, and a potential pharmacological avenue for treating anxiety disorders. |
2008-08-26 |
2023-08-12 |
mouse |
| Naoe Okamura, Rainer K Reinschei. Neuropeptide S: a novel modulator of stress and arousal. Stress (Amsterdam, Netherlands). vol 10. issue 3. 2007-10-02. PMID:17613937. |
nps might interact with other hypothalamic neuropeptide systems that are known to be involved in stress and appetite control and thus might be a valuable target for development of a new class of drugs to treat anxiety disorders. |
2007-10-02 |
2023-08-12 |
Not clear |
| Rainer K Reinscheid, Yan-Ling X. Neuropeptide S and its receptor: a newly deorphanized G protein-coupled receptor system. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 11. issue 6. 2006-01-05. PMID:16282594. |
this unique pharmacological profile of nps offers significant potential for developing new drugs for the treatment of sleep and/or anxiety disorders. |
2006-01-05 |
2023-08-12 |
Not clear |