| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sadegh Ghaderi, Sana Mohammadi, Farzad Fateh. Calcium accumulation or iron deposition: Delving into the temporal sequence of amyotrophic lateral sclerosis pathophysiology in the primary motor cortex. Ibrain. vol 10. issue 3. 2024-09-30. PMID:39346793. |
calcium accumulation or iron deposition: delving into the temporal sequence of amyotrophic lateral sclerosis pathophysiology in the primary motor cortex. |
2024-09-30 |
2024-10-02 |
Not clear |
| Venkateswaran Rajagopalan, Erik P Pior. Differing patterns of cortical grey matter pathology identified by multifractal analysis in UMN-predominant ALS patients with and without corticospinal tract hyperintensity. Journal of the neurological sciences. vol 459. 2024-04-02. PMID:38564847. |
the pathological hallmarks of amyotrophic lateral sclerosis (als) are degeneration of the primary motor cortex grey matter (gm) and corticospinal tract (cst) resulting in upper motor neuron (umn) dysfunction. |
2024-04-02 |
2024-04-05 |
Not clear |
| Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B Relvas, Ana M Sebastião, Sandra H Va. Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1 Neurobiology of disease. 2024-02-09. PMID:38336279. |
communication defects with astroglia contribute to early impairments in the motor cortex plasticity of sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (m1). |
2024-02-09 |
2024-02-12 |
Not clear |
| Robert B Kargb. Microbiome-Gut-Brain Axis Modulation: New Approaches in Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis. ACS medicinal chemistry letters. vol 14. issue 7. 2023-07-19. PMID:37465304. |
mitochondrial dysfunction plays a critical role in the disease's progression, while amyotrophic lateral sclerosis (als), or lou gehrig's disease, is a fatal progressive neurodegenerative disease characterized by significant motor neuron loss in the primary motor cortex, brainstem, and spinal cord. |
2023-07-19 |
2023-08-14 |
Not clear |
| b' Maru\\xc5\\xa1a Barbo, Metka Ravnik-Glava\\xc4\\x8. Extracellular Vesicles as Potential Biomarkers in Amyotrophic Lateral Sclerosis. Genes. vol 14. issue 2. 2023-02-25. PMID:36833252.' |
amyotrophic lateral sclerosis (als) is described as a fatal and rapidly progressive neurodegenerative disorder caused by the degeneration of upper motor neurons in the primary motor cortex and lower motor neurons of the brainstem and spinal cord. |
2023-02-25 |
2023-08-14 |
Not clear |
| Wataru Sako, Shotaro Haji, Takashi Abe, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada, Yuishin Izum. M1/precuneus ratio as a surrogate marker of upper motor neuron sign in ALS. Journal of the neurological sciences. vol 445. 2023-01-14. PMID:36640663. |
to investigate whether primary motor cortex (m1) volume measured with an automated approach in mri reflects upper motor neuron dysfunction and whether it can serve as a potential diagnostic and/or disease-tracking biomarker for amyotrophic lateral sclerosis (als). |
2023-01-14 |
2023-08-14 |
Not clear |
| Avyarthana Dey, Collin C Luk, Abdullah Ishaque, Daniel Ta, Ojas Srivastava, Dennell Krebs, Peter Seres, Chris Hanstock, Christian Beaulieu, Lawrence Korngut, Richard Frayne, Lorne Zinman, Simon Graham, Angela Genge, Hannah Briemberg, Sanjay Kalr. Motor cortex functional connectivity is associated with underlying neurochemistry in ALS. Journal of neurology, neurosurgery, and psychiatry. 2022-11-15. PMID:36379713. |
to identify structural and neurochemical properties that underlie functional connectivity impairments of the primary motor cortex (pmc) and how these relate to clinical findings in amyotrophic lateral sclerosis (als). |
2022-11-15 |
2023-08-14 |
Not clear |
| Tiffany Y S. Editorial Comment: Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases. European radiology. 2022-09-08. PMID:36074266. |
• conventional and advanced mr techniques may aid in the diagnosis of motor neuron disease.• iron-sensitive mr imaging of the primary motor cortex may reveal changes to help differentiate hereditary spastic paraplegia (hsp) from umm predominant amyotrophic lateral sclerosis (umn-als) and primary lateral sclerosis (pls).• additional research in this area is necessary. |
2022-09-08 |
2023-08-14 |
Not clear |
| Mauro Costagli, Graziella Donatelli, Paolo Cecchi, Paolo Bosco, Gianmichele Migaleddu, Gabriele Siciliano, Mirco Cosottin. Distribution Indices of Magnetic Susceptibility Values in the Primary Motor Cortex Enable to Classify Patients with Amyotrophic Lateral Sclerosis. Brain sciences. vol 12. issue 7. 2022-07-27. PMID:35884748. |
distribution indices of magnetic susceptibility values in the primary motor cortex enable to classify patients with amyotrophic lateral sclerosis. |
2022-07-27 |
2023-08-14 |
human |
| Mauro Costagli, Graziella Donatelli, Paolo Cecchi, Paolo Bosco, Gianmichele Migaleddu, Gabriele Siciliano, Mirco Cosottin. Distribution Indices of Magnetic Susceptibility Values in the Primary Motor Cortex Enable to Classify Patients with Amyotrophic Lateral Sclerosis. Brain sciences. vol 12. issue 7. 2022-07-27. PMID:35884748. |
quantitative susceptibility mapping (qsm) can measure iron concentration increase in the primary motor cortex (m1) of patients with amyotrophic lateral sclerosis (als). |
2022-07-27 |
2023-08-14 |
human |
| Sanjay Das, A Nalini, T R Laxmi, T R Raj. ALS-CSF-induced structural changes in spinal motor neurons of rat pups cause deficits in motor behaviour. Experimental brain research. vol 239. issue 1. 2021-07-28. PMID:33170340. |
amyotrophic lateral sclerosis (als) is a late-onset, neurodegenerative disease associated with the loss of motor neurons in the spinal cord, brain stem and primary motor cortex. |
2021-07-28 |
2023-08-13 |
rat |
| Matthew Nolan, Connor Scott, Menuka Pallebage Gamarallage, Daniel Lunn, Kilda Carpenter, Elizabeth McDonough, Dan Meyer, Sireesha Kaanumalle, Alberto Santamaria-Pang, Martin R Turner, Kevin Talbot, Olaf Ansorg. Quantitative patterns of motor cortex proteinopathy across ALS genotypes. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32616036. |
degeneration of the primary motor cortex is a defining feature of amyotrophic lateral sclerosis (als), which is associated with the accumulation of microscopic protein aggregates in neurons and glia. |
2021-05-31 |
2023-08-13 |
Not clear |
| Giorgio Conte, Sara Sbaraini, Claudia Morelli, Silvia Casale, Luca Caschera, Valeria Elisa Contarino, Elisa Scola, Claudia Cinnante, Francesca Trogu, Fabio Triulzi, Vincenzo Silan. A susceptibility-weighted imaging qualitative score of the motor cortex may be a useful tool for distinguishing clinical phenotypes in amyotrophic lateral sclerosis. European radiology. vol 31. issue 3. 2021-04-14. PMID:32886203. |
to distinguish amyotrophic lateral sclerosis (als) and its subtypes from als mimics and healthy controls based on the assessment of iron-related hypointensity of the primary motor cortex in susceptibility-weighted imaging (swi). |
2021-04-14 |
2023-08-13 |
Not clear |
| Hironobu Endo, Kenji Sekiguchi, Takehiro Ueda, Hisatomo Kowa, Fumio Kanda, Tatsushi Tod. Regional glucose hypometabolic spread within the primary motor cortex is associated with amyotrophic lateral sclerosis disease progression: A fluoro-deoxyglucose positron emission tomography study. eNeurologicalSci. vol 6. 2020-10-01. PMID:29260014. |
regional glucose hypometabolic spread within the primary motor cortex is associated with amyotrophic lateral sclerosis disease progression: a fluoro-deoxyglucose positron emission tomography study. |
2020-10-01 |
2023-08-13 |
Not clear |
| Agessandro Abrahao, Ying Meng, Maheleth Llinas, Yuexi Huang, Clement Hamani, Todd Mainprize, Isabelle Aubert, Chinthaka Heyn, Sandra E Black, Kullervo Hynynen, Nir Lipsman, Lorne Zinma. First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature communications. vol 10. issue 1. 2020-01-06. PMID:31558719. |
we conducted a single-arm, first-in-human trial to investigate the safety and feasibility of mrgfus-induced bbb opening in eloquent primary motor cortex in four volunteers with amyotrophic lateral sclerosis (als). |
2020-01-06 |
2023-08-13 |
human |
| Andres Trostchansk. Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS). Advances in experimental medicine and biology. vol 1161. 2019-10-02. PMID:31562633. |
amyotrophic lateral sclerosis (als) is a multifactorial neurodegenerative disease involving motor neuron (mn) degeneration in the spinal cord, brain stem and primary motor cortex. |
2019-10-02 |
2023-08-13 |
Not clear |
| G Donatelli, A Retico, E Caldarazzo Ienco, P Cecchi, M Costagli, D Frosini, L Biagi, M Tosetti, G Siciliano, M Cosottin. Semiautomated Evaluation of the Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis at 3T. AJNR. American journal of neuroradiology. vol 39. issue 1. 2019-05-29. PMID:29122765. |
semiautomated evaluation of the primary motor cortex in patients with amyotrophic lateral sclerosis at 3t. |
2019-05-29 |
2023-08-13 |
Not clear |
| G Donatelli, A Retico, E Caldarazzo Ienco, P Cecchi, M Costagli, D Frosini, L Biagi, M Tosetti, G Siciliano, M Cosottin. Semiautomated Evaluation of the Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis at 3T. AJNR. American journal of neuroradiology. vol 39. issue 1. 2019-05-29. PMID:29122765. |
in amyotrophic lateral sclerosis, pathologic changes in the primary motor cortex include betz cell depletion and the presence of reactive iron-loaded microglia, detectable on 7t mr images as atrophy and t2*-hypointensity. |
2019-05-29 |
2023-08-13 |
Not clear |
| G Donatelli, A Retico, E Caldarazzo Ienco, P Cecchi, M Costagli, D Frosini, L Biagi, M Tosetti, G Siciliano, M Cosottin. Semiautomated Evaluation of the Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis at 3T. AJNR. American journal of neuroradiology. vol 39. issue 1. 2019-05-29. PMID:29122765. |
our purposes were the following: 1) to investigate the signal hypointensity-to-thickness ratio of the primary motor cortex as a radiologic marker of upper motor neuron involvement in amyotrophic lateral sclerosis with a semiautomated method at 3t, 2) to compare 3t and 7t results, and 3) to evaluate whether semiautomated measurement outperforms visual image assessment. |
2019-05-29 |
2023-08-13 |
Not clear |
| Barbara Commisso, Lingjun Ding, Karl Varadi, Martin Gorges, David Bayer, Tobias M Boeckers, Albert C Ludolph, Jan Kassubek, Oliver J Müller, Francesco Rosell. Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9. eLife. vol 7. 2019-01-21. PMID:30136928. |
amyotrophic lateral sclerosis (als) is characterized by the progressive degeneration of motoneurons in the primary motor cortex (pmo) and in spinal cord. |
2019-01-21 |
2023-08-13 |
mouse |