All Relations between Amyotrophic Lateral Sclerosis and cerebral cortex

Publication Sentence Publish Date Extraction Date Species
Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Francesco Frecentese, Valeria Valsecchi, Giovanna Lombardi, Serenella Anzilotti, Giorgia Andreozzi, Antonia Scognamiglio, Rosa Sparaco, Elisa Perissutti, Beatrice Severino, Michele Gargiulo, Vincenzo Santagada, Giuseppe Pignatar. Newly Synthesized Indolylacetic Derivatives Reduce Tumor Necrosis Factor-Mediated Neuroinflammation and Prolong Survival in Amyotrophic Lateral Sclerosis Mice. ACS pharmacology & translational science. vol 7. issue 7. 2024-07-18. PMID:39022351. the debilitating neurodegenerative disease known as amyotrophic lateral sclerosis (als) is characterized by the progressive loss of motor neurons (mns) in the brain, spinal cord, and motor cortex. 2024-07-18 2024-07-20 mouse
Ermanna Turano, Federica Virla, Ilaria Scambi, Sylwia Dabrowska, Oluwamolakun Bankole, Raffaella Mariott. Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally. European journal of histochemistry : EJH. vol 68. issue 3. 2024-07-04. PMID:38963135. amyotrophic lateral sclerosis (als) is a neurodegenerative disorder involving motor neuron (mn) loss in the motor cortex, brainstem and spinal cord leading to progressive paralysis and death. 2024-07-04 2024-07-10 mouse
Marlene Tahedl, Ee Ling Tan, Jana Kleinerova, Siobhan Delaney, Jennifer C Hengeveld, Mark A Doherty, Russell L Mclaughlin, Pierre-Francois Pradat, Cédric Raoul, Fabrice Ango, Orla Hardiman, Kai Ming Chang, Jasmin Lope, Peter Bed. Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis. Neurology. vol 103. issue 2. 2024-06-20. PMID:38900989. amyotrophic lateral sclerosis (als) is predominantly associated with motor cortex, corticospinal tract (cst), brainstem, and spinal cord degeneration, and cerebellar involvement is much less well characterized. 2024-06-20 2024-06-23 Not clear
Andrea Salzinger, Vidya Ramesh, Shreya Das Sharma, Siddharthan Chandran, Bhuvaneish Thangaraj Selvara. Neuronal Circuit Dysfunction in Amyotrophic Lateral Sclerosis. Cells. vol 13. issue 10. 2024-05-24. PMID:38786016. the primary neural circuit affected in amyotrophic lateral sclerosis (als) patients is the corticospinal motor circuit, originating in upper motor neurons (umns) in the cerebral motor cortex which descend to synapse with the lower motor neurons (lmns) in the spinal cord to ultimately innervate the skeletal muscle. 2024-05-24 2024-05-27 human
Ilaria Martinelli, Jessica Mandrioli, Andrea Ghezzi, Elisabetta Zucchi, Giulia Gianferrari, Cecilia Simonini, Francesco Cavallieri, Franco Valzani. Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients: a rare occurrence? Neural regeneration research. vol 20. issue 1. 2024-05-20. PMID:38767482. amyotrophic lateral sclerosis (als) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. 2024-05-20 2024-05-27 human
Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotte. Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia. Brain : a journal of neurology. 2024-05-04. PMID:38703371. pathogenic variants in the ubqln2 gene cause x-linked dominant amyotrophic lateral sclerosis and/or frontotemporal dementia characterised by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus, and spinal cord. 2024-05-04 2024-05-07 Not clear
Sharon Natasha Cox, Claudio Lo Giudice, Anna Lavecchia, Maria Luana Poeta, Matteo Chiara, Ernesto Picardi, Graziano Pesol. Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672428. amyotrophic lateral sclerosis (als) is a progressive disease with prevalent mitochondrial dysfunctions affecting both upper and lower motor neurons in the motor cortex, brainstem, and spinal cord. 2024-04-27 2024-04-29 human
LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. 2024-03-19 2024-03-21 human
Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouau. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science translational medicine. vol 16. issue 738. 2024-03-13. PMID:38478631. amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by the death of upper (umn) and lower motor neurons (lmn) in the motor cortex, brainstem, and spinal cord. 2024-03-13 2024-03-16 mouse
G Lorenzo Odierna, Steve Vucic, Marcus Dyer, Tracey Dickson, Adele Woodhouse, Catherine Blizzar. How do we get from hyperexcitability to excitotoxicity in amyotrophic lateral sclerosis? Brain : a journal of neurology. 2024-02-26. PMID:38408864. evidence of increased circulating glutamate and hyperexcitability of the motor cortex in patients with amyotrophic lateral sclerosis have provided an empirical support base for the 'dying forward' excitotoxicity hypothesis. 2024-02-26 2024-03-02 Not clear
Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B Relvas, Ana M Sebastião, Sandra H Va. Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1 Neurobiology of disease. 2024-02-09. PMID:38336279. communication defects with astroglia contribute to early impairments in the motor cortex plasticity of sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (m1). 2024-02-09 2024-02-12 Not clear
Patrizia Ratano, Germana Cocozza, Cecilia Pinchera, Ludovica Maria Busdraghi, Iva Cantando, Katiuscia Martinello, Mariarosaria Scioli, Maria Rosito, Paola Bezzi, Sergio Fucile, Heike Wulff, Cristina Limatola, Giuseppina D'Alessandr. Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. Frontiers in molecular neuroscience. vol 16. 2024-01-31. PMID:38292023. amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with no effective therapy, causing progressive loss of motor neurons in the spinal cord, brainstem, and motor cortex. 2024-01-31 2024-02-02 mouse
Matthew Nolan, Connor Scott, Patrick R Hof, Olaf Ansorg. Betz cells of the primary motor cortex. The Journal of comparative neurology. vol 532. issue 1. 2024-01-30. PMID:38289193. this has implications for the modeling of disorders that affect the motor cortex in humans, such as amyotrophic lateral sclerosis (als). 2024-01-30 2024-02-01 human
Jian Lu, An-Xu He, Zhuo-Ying Jin, Meng Zhang, Zhong-Xin Li, Fan Zhou, Lin Ma, Hong-Ming Jin, Jia-Ying Wang, Xu She. Desloratadine alleviates ALS-like pathology in hSOD1 Acta pharmacologica Sinica. 2024-01-29. PMID:38286832. desloratadine alleviates als-like pathology in hsod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord, cerebral cortex and brain stem. 2024-01-29 2024-02-01 Not clear
Samuel Lundt, Nannan Zhang, Luis Polo-Parada, Xinglong Wang, Shinghua Din. Dietary NMN supplementation enhances motor and NMJ function in ALS. Experimental neurology. 2024-01-24. PMID:38266764. amyotrophic lateral sclerosis (als) is an adult-onset neurodegenerative disease that causes the degeneration of motor neurons in the motor cortex and spinal cord. 2024-01-24 2024-01-27 Not clear
Rachel Waller, Joanna J Bury, Charlie Appleby-Mallinder, Matthew Wyles, George Loxley, Aditi Babel, Saleh Shekari, Mbombe Kazoka, Helen Wollff, Ammar Al-Chalabi, Paul R Heath, Pamela J Shaw, Janine Kirb. Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival. Brain communications. vol 6. issue 1. 2024-01-01. PMID:38162899. amyotrophic lateral sclerosis is a fatal neurodegenerative disease, associated with the degeneration of both upper and lower motor neurons of the motor cortex, brainstem and spinal cord. 2024-01-01 2024-01-05 Not clear
Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Li. RABGGTB plays a critical role in ALS pathogenesis. Brain research bulletin. 2023-12-02. PMID:38042502. amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease. 2023-12-02 2023-12-10 Not clear
Elisa Duranti, Chiara Vill. Muscle Involvement in Amyotrophic Lateral Sclerosis: Understanding the Pathogenesis and Advancing Therapeutics. Biomolecules. vol 13. issue 11. 2023-11-25. PMID:38002264. amyotrophic lateral sclerosis (als) is a fatal condition characterized by the selective loss of motor neurons in the motor cortex, brainstem, and spinal cord. 2023-11-25 2023-11-28 Not clear
Lijun Zhou, Wenzhi Chen, Shishi Jiang, Renshi X. In Vitro Models of Amyotrophic Lateral Sclerosis. Cellular and molecular neurobiology. 2023-10-23. PMID:37870685. amyotrophic lateral sclerosis (als) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive death of motor neurons in the cerebral cortex, brain stem and spinal cord. 2023-10-23 2023-11-08 Not clear
Xinxin Wang, Yushu Hu, Renshi X. The pathogenic mechanism of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843214. the onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex, basal ganglia, brainstem, and spinal cord, and commonly involves the muscles of the upper and/or lower extremities, and the muscles of the bulbar and/or respiratory regions. 2023-10-16 2023-11-08 Not clear