| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joshua J Crose, Arezou Crose, John T Ransom, Amy L Lightne. Bone marrow mesenchymal stem cell-derived extracellular vesicle infusion for amyotrophic lateral sclerosis. Neurodegenerative disease management. vol 14. issue 3-4. 2024-10-01. PMID:39352708. |
bone marrow mesenchymal stem cell-derived extracellular vesicle infusion for amyotrophic lateral sclerosis. |
2024-10-01 |
2024-10-03 |
Not clear |
| Alberto Catanese, Sandeep Rajkumar, Daniel Sommer, Pegah Masrori, Nicole Hersmus, Philip Van Damme, Simon Witzel, Albert Ludolph, Ritchie Ho, Tobias M Boeckers, Medhanie Mula. Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis. Brain : a journal of neurology. vol 146. issue 9. 2023-09-02. PMID:36883643. |
notably, the overrepresentation of this biological term also correlated with the transcriptional signature identified in mutant human induced pluripotent stem cell-derived motor neurons, highlighting novel insights into amyotrophic lateral sclerosis marker genes in a tissue-independent manner. |
2023-09-02 |
2023-09-07 |
human |
| Francesco Limone, Joseph R Klim, Daniel A Morde. Pluripotent stem cell strategies for rebuilding the human brain. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408113. |
in this review, we cover advances in methods used to differentiate human pluripotent stem cells into several highly specialized types of neurons, including cholinergic, dopaminergic, and motor neurons, and the potential clinical applications of stem cell-derived neurons for common neurodegenerative diseases, including alzheimer's disease, parkinson's disease, huntington's disease, ataxia, and amyotrophic lateral sclerosis. |
2022-11-21 |
2023-08-14 |
human |
| Yingying Ding, Benson O A Botchway, Yong Zhang, Tian Jin, Xuehong Li. The Combination of Autologous Mesenchymal Stem cell-derived Exosomes and Neurotrophic Factors as an Intervention for Amyotrophic Lateral Sclerosis. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022-03-12. PMID:35278658. |
the combination of autologous mesenchymal stem cell-derived exosomes and neurotrophic factors as an intervention for amyotrophic lateral sclerosis. |
2022-03-12 |
2023-08-13 |
Not clear |
| Bochao Liu, Mo Li, Lingyan Zhang, Zhiguo Chen, Paul L. Motor neuron replacement therapy for amyotrophic lateral sclerosis. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017408. |
stem cell therapy for amyotrophic lateral sclerosis is a very attractive strategy for both basic and clinical researchers, particularly as transplanted stem cells and stem cell-derived neural progenitor/precursor cells can protect endogenous motor neurons and directly replace the lost or dying motor neurons. |
2022-01-12 |
2023-08-13 |
human |
| Jie Wang, Weiwei Hu, Zehua Feng, Meijiang Fen. BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice. Neurological research. vol 43. issue 3. 2021-10-26. PMID:33076784. |
bdnf-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice. |
2021-10-26 |
2023-08-13 |
mouse |
| Wen-Chao Liu, Na Liu, Yan Wang, Chen Huang, Yan-Fang Li, Hao Wang, Xiao-Gang Li, Min Den. Induced pluripotent stem cell-derived motor neurons from amyotrophic lateral sclerosis (ALS) patients carrying different superoxide dismutase 1 mutations recapitulate pathological features of ALS. Chinese medical journal. vol 134. issue 20. 2021-10-22. PMID:34669638. |
induced pluripotent stem cell-derived motor neurons from amyotrophic lateral sclerosis (als) patients carrying different superoxide dismutase 1 mutations recapitulate pathological features of als. |
2021-10-22 |
2023-08-13 |
Not clear |
| Arens Taga, Christa W Habela, Alexandra Johns, Shiyu Liu, Mollie O'Brien, Nicholas J Maragaki. Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons. Journal of visualized experiments : JoVE. issue 174. 2021-10-15. PMID:34515684. |
human pluripotent stem cell-derived astrocytes (hipsc-a) and neurons (hipsc-n) provide a powerful tool for modeling amyotrophic lateral sclerosis (als) pathophysiology in vitro. |
2021-10-15 |
2023-08-13 |
human |
| Nidaa A Ababneh, Jakub Scaber, Rowan Flynn, Andrew Douglas, Paola Barbagallo, Ana Candalija, Martin R Turner, David Sims, Ruxandra Dafinca, Sally A Cowley, Kevin Talbo. Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair. Human molecular genetics. vol 29. issue 13. 2021-08-20. PMID:32504093. |
correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in c9orf72 by crispr/cas9 genome editing using homology-directed repair. |
2021-08-20 |
2023-08-13 |
Not clear |
| Martin L Tomov, Alison O'Neil, Hamdah S Abbasi, Beth A Cimini, Anne E Carpenter, Lee L Rubin, Mark Bath. Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34168275. |
human induced pluripotent stem cell-derived (ipsc) neural cultures offer clinically relevant models of human diseases, including amyotrophic lateral sclerosis, alzheimer's, and autism spectrum disorder. |
2021-08-16 |
2023-08-13 |
human |
| Svitlana Garbuzova-Davis, Cesario V Borlonga. Stem cell-derived extracellular vesicles as potential mechanism for repair of microvascular damage within and outside of the central nervous system in amyotrophic lateral sclerosis: perspective schema. Neural regeneration research. vol 16. issue 4. 2021-07-21. PMID:33063723. |
stem cell-derived extracellular vesicles as potential mechanism for repair of microvascular damage within and outside of the central nervous system in amyotrophic lateral sclerosis: perspective schema. |
2021-07-21 |
2023-08-13 |
Not clear |
| Tadashi Sunohara, Asuka Morizane, Satoshi Matsuura, Susumu Miyamoto, Hirohide Saito, Jun Takahash. MicroRNA-Based Separation of Cortico-Fugal Projection Neuron-Like Cells Derived From Embryonic Stem Cells. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31708734. |
the purification of pluripotent stem cell-derived cortico-fugal projection neurons (psc-cfupns) is useful for disease modeling and cell therapies related to the dysfunction of cortical motor neurons, such as amyotrophic lateral sclerosis (als) or stroke. |
2020-09-29 |
2023-08-13 |
mouse |
| Wangchao Xu, Puhua Bao, Xin Jiang, Haifang Wang, Meiling Qin, Ruiqi Wang, Tao Wang, Yi Yang, Ileana Lorenzini, Lujian Liao, Rita Sattler, Jin X. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity. Brain : a journal of neurology. vol 142. issue 5. 2020-03-03. PMID:30938419. |
bioinformatic analysis of multiple transcriptome profiles revealed significant overlap of upregulated genes in nmd-defective cells with those in the brain tissues, micro-dissected motor neurons, or induced pluripotent stem cell-derived motor neurons specifically from amyotrophic lateral sclerosis patients carrying c9orf72 hexanucleotide repeat expansion, suggesting the suppression of nmd pathway in these patients. |
2020-03-03 |
2023-08-13 |
mouse |
| Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath, Michel Reve. Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1 Stem cell research & therapy. vol 9. issue 1. 2019-03-12. PMID:29871694. |
safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in sod1 amyotrophic lateral sclerosis (als) is a motor neuron (mn) disease characterized by the loss of mns in the central nervous system. |
2019-03-12 |
2023-08-13 |
human |
| Ruxandra Dafinca, Jakub Scaber, Nida'a Ababneh, Tatjana Lalic, Gregory Weir, Helen Christian, Jane Vowles, Andrew G L Douglas, Alexandra Fletcher-Jones, Cathy Browne, Mahito Nakanishi, Martin R Turner, Richard Wade-Martins, Sally A Cowley, Kevin Talbo. C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Stem cells (Dayton, Ohio). vol 34. issue 8. 2017-12-12. PMID:27097283. |
c9orf72 hexanucleotide expansions are associated with altered endoplasmic reticulum calcium homeostasis and stress granule formation in induced pluripotent stem cell-derived neurons from patients with amyotrophic lateral sclerosis and frontotemporal dementia. |
2017-12-12 |
2023-08-13 |
Not clear |
| Gye Sun Jeon, Wooseok Im, Yu-Mi Shim, Mijung Lee, Myung-Jin Kim, Yoon-Ho Hong, Seung-Yong Seong, Manho Kim, Jung-Joon Sun. Neuroprotective Effect of Human Adipose Stem Cell-Derived Extract in Amyotrophic Lateral Sclerosis. Neurochemical research. vol 41. issue 4. 2016-11-10. PMID:26646002. |
neuroprotective effect of human adipose stem cell-derived extract in amyotrophic lateral sclerosis. |
2016-11-10 |
2023-08-13 |
mouse |
| Charles Nicaise, Dinko Mitrecic, Aditi Falnikar, Angelo C Lepor. Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury. World journal of stem cells. vol 7. issue 2. 2015-03-27. PMID:25815122. |
transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury. |
2015-03-27 |
2023-08-13 |
human |
| Mark E Hester, Matthew J Murtha, SungWon Song, Meghan Rao, Carlos J Miranda, Kathrin Meyer, Jinbin Tian, Gabriella Boulting, David V Schaffer, Michael X Zhu, Samuel L Pfaff, Fred H Gage, Brian K Kaspa. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Molecular therapy : the journal of the American Society of Gene Therapy. vol 19. issue 10. 2012-02-03. PMID:21772256. |
stem cell-derived motor neurons (mns) are increasingly utilized for modeling disease in vitro and for developing cellular replacement strategies for spinal cord injury and diseases such as spinal muscular atrophy (sma) and amyotrophic lateral sclerosis (als). |
2012-02-03 |
2023-08-12 |
human |
| Jason R Thonhoff, Luis Ojeda, Ping W. Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis. Current stem cell research & therapy. vol 4. issue 3. 2009-12-04. PMID:19492980. |
stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis. |
2009-12-04 |
2023-08-12 |
Not clear |