| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruihua Liu, Linli Guo, Yanan Zhao, Dan Wu, Jiasi Yu, Ping Li. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu Brain research. 2024-03-05. PMID:38442843. |
study on multi-target effects of the novel hdac6 inhibitor w5 on aβ/cu histone deacetylase 6 (hdac6) is a key therapeutic target in neurodegenerative diseases such as alzheimer's disease (ad), which has been demonstrated to play an essential role in memory function and microtubule-associated tau physiology. |
2024-03-05 |
2024-03-08 |
rat |
| Tetsuro Tago, Muneyuki Sakata, Masakatsu Kanazawa, Shigeyuki Yamamoto, Kenji Ishii, Jun Toyohar. Preclinical validation of a novel brain-penetrant PET ligand for visualization of histone deacetylase 6: a potential imaging target for neurodegenerative diseases. European journal of nuclear medicine and molecular imaging. 2024-03-05. PMID:38441662. |
histone deacetylase 6 (hdac6) has emerged as a therapeutic target for neurodegenerative diseases such as alzheimer's disease. |
2024-03-05 |
2024-03-07 |
Not clear |
| Wen Wen, Jiadong Hu, Chenxi Wang, Rui Yang, Yabo Zhang, Baibei Huang, Tingting Qiao, Jiayun Wang, Xin Che. Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities. Bioorganic & medicinal chemistry letters. 2024-02-22. PMID:38387692. |
histone deacetylase 6 (hdac6) has drawn more and more attention for its potential application in alzheimer's disease (ad) therapy. |
2024-02-22 |
2024-02-25 |
Not clear |
| Prasenjit Mondal, Ping Bai, Ashley Gomm, Grisilda Bakiasi, Chih-Chung Jerry Lin, Yanli Wang, Se Hoon Choi, Rudolph E Tanzi, Changning Wang, Can Zhan. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-11-22. PMID:37990786. |
considerable evidence suggests that hdac6 is closely related to amyloid and tau pathology, the two primary hallmarks of alzheimer's disease (ad). |
2023-11-22 |
2023-11-29 |
Not clear |
| Prasenjit Mondal, Ping Bai, Ashley Gomm, Grisilda Bakiasi, Chih-Chung Jerry Lin, Yanli Wang, Se Hoon Choi, Rudolph E Tanzi, Changning Wang, Can Zhan. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-11-22. PMID:37990786. |
structure-based discovery of a small molecule inhibitor of histone deacetylase 6 (hdac6) that significantly reduces alzheimer's disease neuropathology. |
2023-11-22 |
2023-11-29 |
Not clear |
| Gajendra Choudhary, Manisha Prajapat, Gurjeet Kaur, Harvinder Singh, Saniya Mahendiratta, Ajay Prakash, Bikash Medh. Integrated in-silico and in-vitro assessments of HDAC6 inhibitor efficacy in mitigating amyloid beta pathology in Alzheimer's disease. Journal of biomolecular structure & dynamics. 2023-10-25. PMID:37878051. |
integrated in-silico and in-vitro assessments of hdac6 inhibitor efficacy in mitigating amyloid beta pathology in alzheimer's disease. |
2023-10-25 |
2023-11-08 |
Not clear |
| Lei Wang, Tianyu Sun, Zhenqi Wang, Hui Liu, Weimin Qiu, Xu Tang, Huanchao Guo, Peng Yang, Yao Chen, Haopeng Su. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. 2023-08-10. PMID:37561893. |
concomitant inhibition of butyrylcholinesterase (bche) and histone deacetylase 6 (hdac6) is supposed to be effective in the treatment of alzheimer's disease (ad). |
2023-08-10 |
2023-08-16 |
Not clear |
| Lei Wang, Tianyu Sun, Zhenqi Wang, Hui Liu, Weimin Qiu, Xu Tang, Huanchao Guo, Peng Yang, Yao Chen, Haopeng Su. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. 2023-08-10. PMID:37561893. |
design, synthesis, and proof of concept of balanced dual inhibitors of butyrylcholinesterase (bche) and histone deacetylase 6 (hdac6) for the treatment of alzheimer's disease. |
2023-08-10 |
2023-08-16 |
Not clear |
| Ping Bai, Prasenjit Mondal, Frederick A Bagdasarian, Nisha Rani, Yan Liu, Ashley Gomm, Darcy R Tocci, Se Hoon Choi, Hsiao-Ying Wey, Rudolph E Tanzi, Can Zhang, Changning Wan. Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease. Acta pharmaceutica Sinica. B. vol 12. issue 10. 2022-10-10. PMID:36213537. |
development of a potential pet probe for hdac6 imaging in alzheimer's disease. |
2022-10-10 |
2023-08-14 |
Not clear |
| Ping Bai, Prasenjit Mondal, Frederick A Bagdasarian, Nisha Rani, Yan Liu, Ashley Gomm, Darcy R Tocci, Se Hoon Choi, Hsiao-Ying Wey, Rudolph E Tanzi, Can Zhang, Changning Wan. Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease. Acta pharmaceutica Sinica. B. vol 12. issue 10. 2022-10-10. PMID:36213537. |
although the epigenetic regulatory protein histone deacetylase 6 (hdac6) has been recently implicated in the etiology of alzheimer's disease (ad), little is known about the role of hdac6 in the etiopathogenesis of ad and whether hdac6 can be a potential therapeutic target for ad. |
2022-10-10 |
2023-08-14 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sanjib Senapati, Sandeep Malampati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Benjamin Chun-Kit Tong, King-Ho Cheung, Jie-Qiong Tan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Ju-Xian Song, Min L. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 96. 2021-12-22. PMID:34936968. |
protopine promotes the proteasomal degradation of pathological tau in alzheimer's disease models via hdac6 inhibition. |
2021-12-22 |
2023-08-13 |
Not clear |
| Alexandria M Chan, Steven Fletche. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6. RSC medicinal chemistry. vol 12. issue 2. 2021-12-12. PMID:34046608. |
through its roles in intracellular trafficking, cell motility, mitosis, protein folding and as a back-up to the proteasome pathway, hdac6 has rapidly become an exciting new target for therapeutics, particularly in the discovery of new drugs to treat alzheimer's disease and cancer. |
2021-12-12 |
2023-08-13 |
Not clear |
| Yunheng Li, Shenghu Sang, Weijie Ren, Yuqiong Pei, Yaoyao Bian, Yao Chen, Haopeng Su. Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020). European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34619465. |
inhibition of histone deacetylase 6 (hdac6) as a therapeutic strategy for alzheimer's disease: a review (2010-2020). |
2021-11-22 |
2023-08-13 |
Not clear |
| Xiu-Xiu Wang, Fei Xie, Cong-Cong Jia, Ning Yan, Yan-Li Zeng, Jing-De Wu, Zhao-Peng Li. Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry. vol 225. 2021-11-11. PMID:34517222. |
histone deacetylase 6 (hdac6) is a potential target for alzheimer's disease (ad). |
2021-11-11 |
2023-08-13 |
Not clear |
| Tomohiro Onishi, Ryouta Maeda, Michiko Terada, Sho Sato, Takahiro Fujii, Masahiro Ito, Kentaro Hashikami, Tomohiro Kawamoto, Maiko Tanak. A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34326423. |
a novel orally active hdac6 inhibitor t-518 shows a therapeutic potential for alzheimer's disease and tauopathy in mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Jindong Guo, Meng Lu, Yuhui Zhou, Bowen Wu, Mishan W. Effects of velvet antler polypeptides on Alzheimer's disease cell model via miR-613 HDAC6 pathway. Pakistan journal of pharmaceutical sciences. vol 33. issue 3(Special). 2021-08-06. PMID:33361033. |
effects of velvet antler polypeptides on alzheimer's disease cell model via mir-613 hdac6 pathway. |
2021-08-06 |
2023-08-13 |
Not clear |
| Tetsuro Tago, Jun Toyohara, Kenji Ishi. Preclinical Evaluation of an ACS chemical neuroscience. vol 12. issue 4. 2021-06-18. PMID:33502174. |
hdac6 has emerged as an interesting therapeutic target in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's diseases. |
2021-06-18 |
2023-08-13 |
Not clear |
| Valeria V Kleandrova, Alejandro Speck-Planch. PTML Modeling for Alzheimer's Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6. Current topics in medicinal chemistry. vol 20. issue 19. 2021-06-07. PMID:32515311. |
ptml modeling for alzheimer's disease: design and prediction of virtual multi-target inhibitors of gsk3b, hdac1, and hdac6. |
2021-06-07 |
2023-08-13 |
Not clear |
| Michel Koole, Donatienne Van Weehaeghe, Kim Serdons, Marissa Herbots, Christopher Cawthorne, Sofie Celen, Frederick A Schroeder, Jacob M Hooker, Guy Bormans, Jan de Hoon, Janice E Kranz, Koen Van Laere, Tonya M Gilber. Clinical validation of the novel HDAC6 radiotracer [ European journal of nuclear medicine and molecular imaging. vol 48. issue 2. 2021-05-28. PMID:32638097. |
inhibition of hdac6 deacetylase activity has shown beneficial effects in disease models, including alzheimer's disease and amyotrophic lateral sclerosis. |
2021-05-28 |
2023-08-13 |
Not clear |
| Sofie Celen, Johanna Rokka, Tonya M Gilbert, Michel Koole, Isabeau Vermeulen, Kim Serdons, Frederick A Schroeder, Florence F Wagner, Tom Bleeser, Baileigh G Hightower, Jiyun Hu, Dania Rahal, Hudson Beyzavi, Wim Vanduffel, Koen Van Laere, Janice E Kranz, Jacob M Hooker, Guy Bormans, Christopher J Cawthorn. Translation of HDAC6 PET Imaging Using [ ACS chemical neuroscience. vol 11. issue 7. 2021-04-14. PMID:32159328. |
inhibition of hdac6 can alleviate defects in cell and rodent models of certain diseases, particularly neurodegenerative disorders, including alzheimer's disease and amyotrophic lateral sclerosis. |
2021-04-14 |
2023-08-13 |
Not clear |