All Relations between Alzheimer Disease and Synucleinopathies

Publication Sentence Publish Date Extraction Date Species
Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. 2024-05-06 2024-05-08 mouse
. Expression of Concern: Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer's Diseases. PloS one. vol 18. issue 12. 2023-12-05. PMID:38051714. expression of concern: identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and alzheimer's diseases. 2023-12-05 2023-12-10 Not clear
Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. in addition, alzheimer's tau seeds occur in the vast majority of cases evaluated here inclusive of primary synucleinopathies, frontotemporal lobar degeneration and even controls albeit at multi-log lower levels than alzheimer's cases. 2023-05-08 2023-08-14 Not clear
Jolien Perneel, Manuela Neumann, Bavo Heeman, Simon Cheung, Marleen Van den Broeck, Sarah Wynants, Matt Baker, Cristina T Vicente, Júlia Faura, Rosa Rademakers, Ian R A Mackenzi. Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging. Acta neuropathologica. 2022-12-17. PMID:36527486. accumulation of tmem106b c-terminal immunoreactive (tmem-ir) material was a common finding in all the conditions evaluated, including frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp), alzheimer's disease, tauopathies, synucleinopathies and neurologically normal aging. 2022-12-17 2023-08-14 human
YuHong Fu, Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, Ping Wu, Nicolas Dzamko, Glenda M Halliday, Woojin Scott Ki. Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376990. we were therefore interested in the manifestation of lipid peroxidation in synucleinopathies, a group of neurodegenerative diseases characterized by the central pathology of α-synuclein aggregates, including parkinson's disease, multiple system atrophy, dementia with lewy bodies and alzheimer's disease with lewy bodies. 2022-11-15 2023-08-14 Not clear
Shunsuke Koga, Keith A Josephs, Ikuko Aiba, Mari Yoshida, Dennis W Dickso. Neuropathology and emerging biomarkers in corticobasal syndrome. Journal of neurology, neurosurgery, and psychiatry. 2022-06-13. PMID:35697501. corticobasal degeneration (cbd) is one of the most common underlying pathologies of cbs, but other disorders, such as progressive supranuclear palsy (psp), alzheimer's disease (ad) and frontotemporal lobar degeneration with tdp-43 inclusions, are also associated with this this review, we describe common and rare neuropathological findings in cbs, including tauopathies, synucleinopathies, tdp-43 proteinopathies, fused in sarcoma proteinopathy, prion disease (creutzfeldt-jakob disease) and cerebrovascular disease, based on a narrative review of the literature and clinicopathological studies from two brain banks. 2022-06-13 2023-08-14 Not clear
Tim E Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Gregor Dernick, Wilma D J van de Berg, Markus Britschg. Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies. Acta neuropathologica communications. vol 10. issue 1. 2022-06-06. PMID:35659116. to address this, we generated sequential biochemical extracts of the substantia nigra, putamen and hippocampus from 28 donors diagnosed and neuropathologically-confirmed with different synucleinopathies (pd/pdd/dlb/msa), as well as alzheimer's disease, progressive supranuclear palsy, and aged normal subjects. 2022-06-06 2023-08-14 human
Alice Drobny, Susy Prieto Huarcaya, Jan Dobert, Annika Kluge, Josina Bunk, Theresia Schlothauer, Friederike Zunk. The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches. Biochimica et biophysica acta. Molecular cell research. 2022-02-26. PMID:35217144. particularly, alterations in lysosomal cathepsins ctsd, ctsb and ctsl can contribute to the pathogenesis of neurodegenerative diseases as seen for neuronal ceroid lipofuscinosis, synucleinopathies (parkinson's disease, dementia with lewy body and multiple system atrophy) as well as alzheimer's and huntington disease. 2022-02-26 2023-08-13 Not clear
Wei-Ting Lin, Jin-Siang Shaw, Fang-Yu Cheng, Pei-Hao Che. Plasma total tau predicts executive dysfunction in Parkinson's disease. Acta neurologica Scandinavica. vol 145. issue 1. 2021-12-02. PMID:34398474. amyloid-β and tau pathologies are well-established in alzheimer's disease and commonly coexist with synucleinopathy in pd. 2021-12-02 2023-08-13 human
Andrew D Sauerbeck, Evan Z Goldstein, Anthony N Alfredo, Michael Norenberg, Alexander Marcillo, Dana M McTigu. Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss. Scientific reports. vol 11. issue 1. 2021-11-26. PMID:34083630. interestingly, many pathological mechanisms, including iron accumulation and lipid peroxidation, are shared between classical synucleinopathies such as alzheimer's disease, parkinson's disease and traumatic spinal cord injury (sci). 2021-11-26 2023-08-13 mouse
Samir Abu-Rumeileh, Steffen Halbgebauer, Petra Steinacker, Sarah Anderl-Straub, Barbara Polischi, Albert C Ludolph, Sabina Capellari, Piero Parchi, Markus Ott. CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration. Annals of clinical and translational neurology. vol 7. issue 2. 2021-11-10. PMID:31957347. in alzheimer's disease and synucleinopathies, serpina1 is overexpressed in the brain and the cerebrospinal fluid (csf) showing abnormal patterns of its charge isoforms. 2021-11-10 2023-08-13 Not clear
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. as we have previously demonstrated the presence of α-synuclein deposits in the pancreas of patients with synucleinopathies, as well as tau and aβ deposits in the pancreatic tissue of alzheimer's disease patients, we studied the immunoreactivity of amylin, tau and α-synuclein in the pancreas of 138 subjects with neurodegenerative diseases or type two diabetes and assessed whether the pancreatic β-cells of these subjects present cooccurrence of misfolded proteins. 2021-11-10 2023-08-13 human
Chialin Cheng, Surya A Reis, Emily T Adams, Daniel M Fass, Steven P Angus, Timothy J Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T Wang, Debasis Patnaik, Roberta L Beauchamp, Danielle A Feldman, M Catarina Silva, Mriganka Sur, Gary L Johnson, Vijaya Ramesh, Bruce L Miller, Sally Temple, Kenneth S Kosik, Bradford C Dickerson, Stephen J Haggart. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Scientific reports. vol 11. issue 1. 2021-11-04. PMID:34426604. recently, a p.a152t tau variant was identified as a risk factor for ftd, alzheimer's disease, and synucleinopathies. 2021-11-04 2023-08-13 human
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. abnormal tau can also be observed in secondary tauopathies such as alzheimer's disease (ad) and synucleinopathies such as parkinson's disease (pd). 2021-10-11 2023-08-13 Not clear
Christos Proukaki. Somatic mutations in neurodegeneration: An update. Neurobiology of disease. vol 144. 2021-09-24. PMID:32712267. in common sporadic neurodegenerative disorders, relevant mutations have been reported in synucleinopathies, comprising somatic gains of snca in parkinson's disease and multiple system atrophy, and in alzheimer's disease, where a novel recombination mechanism leading to somatic variants of app, as well as an excess of somatic snvs affecting tau phosphorylation, have been reported. 2021-09-24 2023-08-13 human
Ethan W Hass, Zachary A Sorrentino, Yuxing Xia, Grace M Lloyd, John Q Trojanowski, Stefan Prokop, Benoit I Giasso. Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies. Acta neuropathologica communications. vol 9. issue 1. 2021-09-10. PMID:34454615. synucleinopathies, including parkinson's disease (pd), lewy body dementia (lbd), alzheimer's disease with amygdala restricted lewy bodies (ad/alb), and multiple system atrophy (msa) comprise a spectrum of neurodegenerative disorders characterized by the presence of distinct pathological α-synuclein (αsyn) inclusions. 2021-09-10 2023-08-13 Not clear
Lindsay E Stoyka, Casey L Mahoney, Drake R Thrasher, Drèson L Russell, Anna K Cook, Anner T Harris, Ashwin Narayanan, Tiara P Janado, David G Standaert, Erik D Roberson, Laura A Volpicelli-Dale. Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau. eNeuro. vol 8. issue 3. 2021-07-02. PMID:33972291. reducing endogenous tau levels is protective in multiple models of alzheimer's disease (ad), tauopathies, and in some transgenic synucleinopathy mouse models. 2021-07-02 2023-08-13 mouse
Saranna Fanning, Dennis Selkoe, Ulf Dettme. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinson's disease. vol 6. 2021-06-04. PMID:31909184. the 14 kda protein α-synuclein (αs) is strongly associated with parkinson's disease (pd), dementia with lewy bodies (dlb), other synucleinopathies such as multiple system atrophy, and even certain forms of alzheimer's disease. 2021-06-04 2023-08-13 Not clear
Hideki Oizumi, Kenshi Yamasaki, Hiroyoshi Suzuki, Takafumi Hasegawa, Yoko Sugimura, Toru Baba, Kohji Fukunaga, Atsushi Taked. Fatty Acid-Binding Protein 3 Expression in the Brain and Skin in Human Synucleinopathies. Frontiers in aging neuroscience. vol 13. 2021-04-13. PMID:33841128. here, we histologically studied fabp3 expression in human tissues obtained from patients with synucleinopathies, patients with alzheimer disease (ad) and controls. 2021-04-13 2023-08-13 mouse
Giovanni Bellomo, Federico Paolini Paoletti, Elena Chipi, Maya Petricciuolo, Simone Simoni, Nicola Tambasco, Lucilla Parnett. A/T/(N) Profile in Cerebrospinal Fluid of Parkinson's Disease with/without Cognitive Impairment and Dementia with Lewy Bodies. Diagnostics (Basel, Switzerland). vol 10. issue 12. 2020-12-26. PMID:33256252. neuropathological investigations report that in synucleinopathies with dementia, namely parkinson's disease (pd) with dementia (pdd) and dementia with lewy bodies (dlb), the histopathological hallmarks of alzheimer's disease (ad), in particular amyloid plaques, are frequently observed. 2020-12-26 2023-08-13 Not clear